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刘易斯血型抗原与志贺菌易感性改变有关。

Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.

机构信息

Department of Medicine, Division of International Health and Infectious Diseases, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

出版信息

Clin Infect Dis. 2021 Jun 1;72(11):e868-e871. doi: 10.1093/cid/ciaa1409.

DOI:10.1093/cid/ciaa1409
PMID:32940644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8315233/
Abstract

In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.

摘要

在一组婴儿中，我们发现缺乏 Lewis 组织血型抗原与增加对志贺氏菌病的易感性有关。在体外广泛抑制上皮细胞中的岩藻糖基化可降低福氏志贺菌的侵袭力。这些结果支持糖基化糖在易感性中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ce/8315233/07c362efad3c/ciaa1409_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ce/8315233/07c362efad3c/ciaa1409_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ce/8315233/07c362efad3c/ciaa1409_fig1.jpg

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