Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America.
Ethos Diagnostic Science, San Diego, California, United States of America.
PLoS One. 2020 Sep 17;15(9):e0239223. doi: 10.1371/journal.pone.0239223. eCollection 2020.
Brachycephalic airway syndrome (BAS) is a well-established cause of respiratory distress in dogs. BAS without surgical correction results in eventual laryngeal collapse. Arytenoid lateralization has been used to treat severe laryngeal collapse with some highly variable results. Chondromalacia and decreased stiffness of the arytenoid cartilage has been postulated a source of failure after arytenoid lateralization but no report of the histological characteristics and mechanical strength of arytenoid cartilage in brachycephalic dogs has been reported. Here we report histological and mechanical features in arytenoid cartilage of brachycephalic dogs. We identified the arytenoid cartilage in brachycephalic dogs presented degenerative histological characteristics and decreased load to failure and stiffness compared to that in non-brachycephalic dogs. Together, these observations suggest that degenerative condition of arytenoid cartilage in brachycephalic dogs could contribute to chondromalacia and mechanical weakness of arytenoid cartilage and result in cause of failure after arytenoid lateralization.
短头气道综合征（BAS）是犬呼吸窘迫的一个公认原因。未经手术矫正的 BAS 最终会导致喉塌陷。杓状软骨侧位术已被用于治疗严重的喉塌陷，但结果差异很大。杓状软骨软骨软化和刚性降低被认为是杓状软骨侧位术后失败的原因，但尚无关于短头犬杓状软骨的组织学特征和机械强度的报道。在这里，我们报告了短头犬杓状软骨的组织学和力学特征。我们发现，与非短头犬相比，短头犬的杓状软骨表现出退行性组织学特征，失效载荷和刚度降低。这些观察结果表明，短头犬杓状软骨的退行性病变可能导致杓状软骨软骨软化和机械强度减弱，并导致杓状软骨侧位术后失败。
