College of Chemical Engineering, Xinjiang Agricultural University, Urumchi 830052, Xinjiang, People's Republic of China.
College of Chemical Engineering, Xinjiang Agricultural University, Urumchi 830052, Xinjiang, People's Republic of China.
Int J Biol Macromol. 2020 Dec 1;164:4566-4574. doi: 10.1016/j.ijbiomac.2020.09.072. Epub 2020 Sep 14.
Injectable hydrogels with self-healing ability present great potential for drug delivery. They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites. Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug. The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-FeO, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties. The nano γ-FeO with particle size of about 0.25 μm loaded on the surface of hydrogel. Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g. When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively. The composite hydrogels could continuously release water-soluble 5-FU for more than 12 h. In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems. The addition of γ-FeO could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
具有自修复能力的可注射水凝胶在药物输送方面具有巨大的潜力。它们可以方便地在体内植入，并保持结构和功能的完整性，直到水凝胶到达目标部位。在此，开发了一系列可注射和自修复的复合水凝胶作为抗癌药物的输送载体。这些水凝胶是通过改变氧化果胶/壳聚糖与纳米 γ-FeO 的比例获得的，具有优异的可注射性、自修复性、磁性、高生物相容性和抗癌特性。纳米 γ-FeO 的粒径约为 0.25μm，负载在水凝胶的表面。水凝胶的磁滞回线在施加磁场时呈现出 S 形，MS 值为 4.86 emu/g。当 pH 值从 7.4 降至 6.5 或温度从 36°C 升高到 37°C 时，OP4-400 的溶胀率分别增加了 35.89%和 25.13%。复合水凝胶可以持续释放水溶性 5-FU 超过 12 小时。此外，尽管水凝胶系统中添加了痕量的 5-FU，但药物输送系统仍表现出可接受的抗癌性能。γ-FeO 的添加不仅有利于靶向，而且还可以共同增强抗癌性能。
