Mackillop W J, Dotsikas G
Department of Oncology, Queen's University, Kingston, Ontario, Canada.
Int J Cell Cloning. 1988 May;6(3):161-78. doi: 10.1002/stem.5530060303.
Tumor cell heterogeneity has in recent years been the subject of numerous excellent review articles, but comprehensive reviews may not always distinguish between that which is known about tumors from direct observation and that which is inferred from the study of analagous systems. The purpose of this review is to describe what is known about cellular heterogeneity in human tumors and to discuss current models of the pathogenesis of cellular heterogeneity in light of the evidence available from the study of human cancer.
近年来，肿瘤细胞异质性一直是众多优秀综述文章的主题，但全面的综述可能并不总能区分通过直接观察对肿瘤的了解与从类似系统研究中推断出的内容。本综述的目的是描述关于人类肿瘤细胞异质性的已知情况，并根据人类癌症研究可得的证据，讨论细胞异质性发病机制的当前模型。
