神经元重编程用于脑修复：挑战与展望。
Neuronal Reprogramming for Brain Repair: Challenges and Perspectives.
机构信息
Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Strasse 9, 82152 Planegg/Martinsried, Germany; Helmholtz Center Munich, Biomedical Center (BMC), Institute of Stem Cell Research, Großhaderner Strasse 9, 82152 Planegg/Martinsried, Germany.
Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Strasse 9, 82152 Planegg/Martinsried, Germany; Helmholtz Center Munich, Biomedical Center (BMC), Institute of Stem Cell Research, Großhaderner Strasse 9, 82152 Planegg/Martinsried, Germany; SyNergy Excellence Cluster, Munich, Germany.
出版信息
Trends Mol Med. 2020 Oct;26(10):890-892. doi: 10.1016/j.molmed.2020.08.006. Epub 2020 Sep 14.
Brain injuries and neurodegenerative diseases elicit neuronal loss that persists because the adult mammalian brain lacks robust regenerative abilities. Direct reprogramming of local glial cells into neurons is a promising strategy for neuronal replacement in vivo. We discuss recent advances and future challenges in this approach to brain repair.
脑损伤和神经退行性疾病会引发神经元的丧失，而这种丧失持续存在的原因是成年哺乳动物的大脑缺乏强大的再生能力。将局部神经胶质细胞直接重编程为神经元是一种很有前途的体内神经元替代策略。我们讨论了这种脑修复方法的最新进展和未来挑战。
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