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本文引用的文献

1
Reduced Monocytic Human Leukocyte Antigen-DR Expression Indicates Immunosuppression in Critically Ill COVID-19 Patients.危重症 COVID-19 患者单核细胞 HLA-DR 表达降低提示免疫抑制。
Anesth Analg. 2020 Oct;131(4):993-999. doi: 10.1213/ANE.0000000000005044.
2
Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?COVID-19 患者的合并感染：是否需要使用非抗 SARS-CoV-2 药物进行联合治疗？
J Microbiol Immunol Infect. 2020 Aug;53(4):505-512. doi: 10.1016/j.jmii.2020.05.013. Epub 2020 May 23.
3
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19).新型冠状病毒病（COVID-19）患者 T 细胞减少和功能耗竭。
Front Immunol. 2020 May 1;11:827. doi: 10.3389/fimmu.2020.00827. eCollection 2020.
4
Clinical characteristics and co-infections of 354 hospitalized patients with COVID-19 in Wuhan, China: a retrospective cohort study.中国武汉 354 例 COVID-19 住院患者的临床特征和合并感染：一项回顾性队列研究。
Microbes Infect. 2020 May-Jun;22(4-5):195-199. doi: 10.1016/j.micinf.2020.05.007. Epub 2020 May 18.
5
The laboratory tests and host immunity of COVID-19 patients with different severity of illness.不同疾病严重程度的 COVID-19 患者的实验室检测和宿主免疫。
JCI Insight. 2020 May 21;5(10):137799. doi: 10.1172/jci.insight.137799.
6
CoViD-19 Immunopathology and Immunotherapy.新型冠状病毒肺炎的免疫病理学与免疫治疗
Bioinformation. 2020 Mar 31;16(3):219-222. doi: 10.6026/97320630016219. eCollection 2020.
7
Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia.新型冠状病毒肺炎外周血淋巴细胞亚群特征变化。
J Infect Dis. 2020 May 11;221(11):1762-1769. doi: 10.1093/infdis/jiaa150.
8
Clinical and immunological features of severe and moderate coronavirus disease 2019.新型冠状病毒病 2019 重症和中度患者的临床和免疫学特征。
J Clin Invest. 2020 May 1;130(5):2620-2629. doi: 10.1172/JCI137244.
9
Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State.华盛顿州 21 例 COVID-19 危重症患者的特征和结局。
JAMA. 2020 Apr 28;323(16):1612-1614. doi: 10.1001/jama.2020.4326.

SARS-CoV-2 诱导的免疫失调以及 COVID-19 患者需要更高的临床警惕以识别合并感染和继发感染。

SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients.

机构信息

American University of Caribbean, School of Medicine, Sint Maarten.

School of Tropical Medicine and Global Health, Nagasaki University, Japan; Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam.

出版信息

J Microbiol Immunol Infect. 2021 Feb;54(1):105-108. doi: 10.1016/j.jmii.2020.08.016. Epub 2020 Sep 8.

DOI:10.1016/j.jmii.2020.08.016
PMID:32943328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7834067/
Abstract

Cases of co-infection and secondary infection emerging during the current Coronavirus Disease-19 (COVID-19) pandemic are a major public health concern. Such cases may result from immunodysregulation induced by the SARS-CoV-2 virus. Pandemic preparedness must include identification of disease natural history and common secondary infections to implement clinical solutions.

摘要

当前的新型冠状病毒病（COVID-19）大流行期间出现的合并感染和继发感染病例是一个主要的公共卫生关注点。此类病例可能是由 SARS-CoV-2 病毒引起的免疫失调所致。大流行防范必须包括确定疾病自然史和常见的继发感染，以实施临床解决方案。