Department of Microbiology, Faculty of Science, Mahidol University, 272, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
Pornchai Matangkasombut Center for Microbial Genomics (CENMIG), Department of Microbiology, Faculty of Science, Mahidol University, 272, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
Sci Rep. 2020 Sep 17;10(1):15268. doi: 10.1038/s41598-020-72246-6.
In this study, we compiled 84-year worth (1934-2017) of genomic and epidemiological data of foot-and-mouth disease virus (FMDV), and performed comprehensive analyses to determine its early origin and transmission route. We found that recombination is a key feature of FMDV, and that the genomic regions coding for structural and non-structural proteins have markedly different evolutionary histories, and evolve at different rates. Despite all of these differences, analyses of both structural and non-structural protein coding regions consistently suggested that the most recent common ancestor of FMDV could be dated back to the Middle Age, ~ 200 to 300 years earlier than previously thought. The ancestors of the Euro-Asiatic and SAT strains could be dated back to the mid-seventeenth century, and to the mid-fifteenth to mid-sixteenth century, respectively. Our results implicated Mediterranean counties as an early geographical origin of FMDV before spreading to Europe and subsequently to Asia and South America.
在这项研究中，我们汇集了口蹄疫病毒（FMDV）长达 84 年（1934-2017 年）的基因组和流行病学数据，并进行了全面分析，以确定其早期起源和传播途径。我们发现重组是 FMDV 的一个关键特征，编码结构蛋白和非结构蛋白的基因组区域具有明显不同的进化历史，并且以不同的速度进化。尽管存在所有这些差异，但对结构蛋白和非结构蛋白编码区域的分析都一致表明，FMDV 的最近共同祖先可以追溯到中世纪，比之前认为的要早 200 到 300 年。欧亚和 SAT 株的祖先可以追溯到 17 世纪中叶，以及 15 世纪中叶到 16 世纪中叶。我们的研究结果表明，在传播到欧洲、亚洲和南美洲之前，地中海国家是 FMDV 的早期地理起源地。
