Tesfanchal Brhane, Gebremichail Gebremedhin, Belay Getachew, Gebremariam Gebreslassie, Teklehaimanot Gebreyohannes, Haileslasie Hagos, Kahsu Getachew, Gebrewahd Aderajew, Mardu Fitsum, Adhanom Gebre, Berhe Brhane, Teame Hirut, Tsegaye Aster, Wolde Mistire
Unit of Clinical Chemistry, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Unit of Hematology and Immuno-Hematology, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Infect Drug Resist. 2020 Aug 26;13:3055-3062. doi: 10.2147/IDR.S261698. eCollection 2020.
Visceral leishmaniasis causes alterations of lipid metabolism and it is associated with hypocholesterolemia and severe hypertriglyceridemia. Hepatic dysfunction and life-threatening hepatitis are associated with visceral leishmaniasis. Kidney damage is frequently associated with increased morbidity and mortality in visceral leishmaniasis patients.
A cross-sectional study was carried out to assess the alterations of clinical chemistry parameters among visceral leishmaniasis patients attending Kahsay Abera and Mearg hospitals, Northwest Ethiopia. A total of 100 visceral leishmaniasis patients and 100 healthy controls without visceral leishmaniasis were selected by using convenient sampling techniques. Data were entered and analyzed using statistical package for social sciences (SPSS) version 23.
Results were showed that the mean value of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, and triglyceride was significantly higher in visceral leishmaniasis patients than in apparently healthy controls, but the mean value of serum urea and total cholesterol was significantly lower in visceral leishmaniasis patients than healthy controls.
The finding of this study concluded that visceral leishmaniasis causes significant alterations of clinical chemistry tests like liver and lipid profile tests compared to healthy controls.
内脏利什曼病会导致脂质代谢改变，与低胆固醇血症和严重高甘油三酯血症相关。肝功能障碍和危及生命的肝炎与内脏利什曼病有关。肾脏损害常与内脏利什曼病患者发病率和死亡率增加相关。
开展了一项横断面研究，以评估埃塞俄比亚西北部卡赛·阿贝拉医院和梅尔格医院的内脏利什曼病患者临床化学参数的改变情况。采用方便抽样技术，共选取了100例内脏利什曼病患者和100例无内脏利什曼病的健康对照。使用社会科学统计软件包（SPSS）23版录入和分析数据。
结果显示，内脏利什曼病患者血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、总胆红素和甘油三酯的平均值显著高于明显健康的对照，但内脏利什曼病患者血清尿素和总胆固醇的平均值显著低于健康对照。
本研究结果表明，与健康对照相比，内脏利什曼病会导致临床化学检测如肝脏和血脂检测出现显著改变。
