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Leishmaniasis: a review.

作者信息

Torres-Guerrero Edoardo, Quintanilla-Cedillo Marco Romano, Ruiz-Esmenjaud Julieta, Arenas Roberto

机构信息

Sección de Micología, Hospital "Manuel Gea González" Secretaría de Salud, Calz. de Tlalpan 4800, Ciudad de México 14080, Mexico.

Dermatólogo, Clínica Carranza, Chetumal, Quintana Roo, Mexico.

出版信息

F1000Res. 2017 May 26;6:750. doi: 10.12688/f1000research.11120.1. eCollection 2017.

DOI:10.12688/f1000research.11120.1
PMID:28649370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5464238/
Abstract

Leishmaniasis is caused by an intracellular parasite transmitted to humans by the bite of a sand fly. It is endemic in Asia, Africa, the Americas, and the Mediterranean region. Worldwide, 1.5 to 2 million new cases occur each year, 350 million are at risk of acquiring the disease, and leishmaniasis causes 70,000 deaths per year. Clinical features depend on the species of involved and the immune response of the host. Manifestations range from the localized cutaneous to the visceral form with potentially fatal outcomes. Many drugs are used in its treatment, but the only effective treatment is achieved with current pentavalent antimonials.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/7f8269972e66/f1000research-6-11996-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/3f02717d98e0/f1000research-6-11996-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/18b230e77ad0/f1000research-6-11996-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/16a97b5d3198/f1000research-6-11996-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/09090d1266d8/f1000research-6-11996-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/8b9c8b17ee7c/f1000research-6-11996-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/bcbb384a7260/f1000research-6-11996-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/48d7228df3c3/f1000research-6-11996-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/7f8269972e66/f1000research-6-11996-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/3f02717d98e0/f1000research-6-11996-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/18b230e77ad0/f1000research-6-11996-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/16a97b5d3198/f1000research-6-11996-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/09090d1266d8/f1000research-6-11996-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/8b9c8b17ee7c/f1000research-6-11996-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/bcbb384a7260/f1000research-6-11996-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/48d7228df3c3/f1000research-6-11996-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/796f/5464238/7f8269972e66/f1000research-6-11996-g0007.jpg

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[1]
Leishmaniasis: a review.

F1000Res. 2017-5-26

[2]
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[3]
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[10]
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引用本文的文献

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PLoS One. 2025-9-3

[2]
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[3]
Indazole Derivatives Against Murine Cutaneous Leishmaniasis.

Pharmaceuticals (Basel). 2025-7-25

[4]
The Diagnostic Utility of PCR in FFPE Skin Biopsies with Inconclusive Histopathology for Suspected Cutaneous Leishmaniasis: A Pilot Study from Colombia.

Trop Med Infect Dis. 2025-8-18

[5]
Mechanistic Insights and Therapeutic Potential of the Antidepressant Amitriptyline against .

ACS Omega. 2025-8-7

[6]
Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches.

J Cell Biochem. 2025-8

[7]
A 12-year analysis of seasonal patterns and disease dynamics of in Saudi Arabia.

Saudi Med J. 2025-8

[8]
LeishTec vaccination disrupts vertical transmission of Leishmania infantum.

PLoS Negl Trop Dis. 2025-7-30

[9]
Impact of weather extremes on the spatiotemporal dynamics of visceral leishmaniasis in Brazil.

PLoS Negl Trop Dis. 2025-7-28

[10]
Design, Synthesis, and In Vitro Evaluation of the Leishmanicidal Activity of New Aromatic Symmetrical 1,4-Disubstituted 1,2,3-Bistriazoles.

ACS Omega. 2025-5-12

本文引用的文献

[1]
Screening of Novel Inhibitors Against Leishmania donovani Calcium ion Channel to Fight Leishmaniasis.

Infect Disord Drug Targets. 2017

[2]
Visceral leishmaniasis in immunocompromised: diagnostic and therapeutic approach and evaluation of the recently released IDSA guidelines.

Infez Med. 2016-12-1

[3]
The new situation of cutaneous leishmaniasis after Syrian civil war in Gaziantep city, Southeastern region of Turkey.

Acta Trop. 2017-2

[4]
Demographic and spatio-temporal distribution of cutaneous leishmaniasis in the Souf oasis (Eastern South of Algeria): Results of 13 years.

Acta Trop. 2017-2

[5]
Spatial modeling of cutaneous leishmaniasis in Iran from 1983 to 2013.

Acta Trop. 2017-2

[6]
Frequency and diversity of phlebotomine sand flies (Diptera: Psychodidae) in Sinop, State of Mato Grosso, Brazil.

Rev Soc Bras Med Trop. 2016

[7]
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial.

Clin Infect Dis. 2016-11-1

[8]
Worldwide risk factors in leishmaniasis.

Asian Pac J Trop Med. 2016-10

[9]
Epidemiology of American Tegumentary Leishmaniasis and Infection in the Northwestern Argentina.

Biomed Res Int. 2016

[10]
STATUS OF THE AMERICAN TEGUMENTARY LEISHMANIASIS IN THE STATE OF RIO DE JANEIRO , BRAZIL, FROM 2004 TO 2013.

Rev Inst Med Trop Sao Paulo. 2016-9-22

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