Steinhoff Martin, Ammoury Alfred F, Ahmed Haytham Mohamed, Gamal Mohamed Fathy Soliman, El Sayed Mahira H
Department of Dermatology and Venereology, and HMC Translational Research Institute, Hamad Medical Corporation, Qatar University, and Weill Cornell Medical College-Qatar, Doha, Qatar.
Department of Dermatology, Weill Cornell University, New York, NY, USA.
Psoriasis (Auckl). 2020 Aug 20;10:23-28. doi: 10.2147/PTT.S264431. eCollection 2020.
Dermatologists practicing in African and Middle Eastern countries face numerous challenges when managing patients with plaque psoriasis, especially those with disease in a difficult-to-treat anatomic area or those who are a pediatric, geriatric, or pregnant patient. The publication of comprehensive, up-to-date, region-specific clinical guidelines may help to address some of these challenges and improve outcomes. We conducted a literature review to identify recent guidelines and other publications describing patients with plaque psoriasis in Africa and the Middle East.
An online literature search of the PubMed database was conducted to identify publications reporting clinical guidelines and research studies on plaque psoriasis. The search included all articles published from January 2008 to March 2020 inclusive. The titles and abstracts of all search results were screened by a reader to identify those that described patients in Africa or the Middle East.
A total of 145 publications were identified by the literature search and screened by a reader. There were 10 publications that described patients in Africa or the Middle East: 4 research articles, 3 reviews, 2 guidelines, and 1 case study. The 2010 guidelines from South Africa made recommendations for treating plaque psoriasis of varying severity, although without specific recommendations for difficult-to-treat anatomic areas or pediatric, geriatric, or pregnant patients. The 2014 guideline on biologics from Saudi Arabia included recommendations for the use of these agents in patients with plaque psoriasis, including difficult-to-treat anatomic areas and pediatric patients (TNF inhibitors only), but provided no recommendations for pregnant or geriatric patients.
There is an urgent unmet need for comprehensive clinical guidelines on the management of patients with plaque psoriasis in Africa and the Middle East. Region-specific studies on the epidemiology, burden of disease, and the safety and effectiveness of newer pharmacotherapies are needed to support the development of such guidelines.
在非洲和中东国家执业的皮肤科医生在治疗斑块状银屑病患者时面临诸多挑战，尤其是那些病变位于难以治疗的解剖部位的患者，以及儿科、老年或妊娠患者。发布全面、最新的、针对特定区域的临床指南可能有助于应对其中一些挑战并改善治疗效果。我们进行了一项文献综述，以确定近期描述非洲和中东地区斑块状银屑病患者的指南及其他出版物。
对PubMed数据库进行在线文献检索，以确定报告斑块状银屑病临床指南和研究的出版物。检索范围包括2008年1月至2020年3月期间发表的所有文章。由一名读者筛选所有检索结果的标题和摘要，以确定那些描述非洲或中东地区患者的文章。
通过文献检索共识别出145篇出版物，并由一名读者进行筛选。有10篇出版物描述了非洲或中东地区的患者：4篇研究文章、3篇综述、2篇指南和1篇病例报告。南非2010年的指南针对不同严重程度的斑块状银屑病治疗提出了建议，不过对于难以治疗的解剖部位或儿科、老年或妊娠患者没有具体建议。沙特阿拉伯2014年关于生物制剂的指南包括了在斑块状银屑病患者中使用这些药物的建议，包括难以治疗的解剖部位和儿科患者（仅针对肿瘤坏死因子抑制剂），但未针对妊娠或老年患者提供建议。
非洲和中东地区迫切需要关于斑块状银屑病患者管理的全面临床指南。需要开展针对特定区域的流行病学、疾病负担以及新型药物疗法安全性和有效性的研究，以支持此类指南的制定。
