Suppr超能文献

光疗在老年患者中的疗效与安全性:一项回顾性研究。

The efficacy and safety of phototherapy in geriatric patients: a retrospective study.

作者信息

Bulur Isil, Erdogan Hilal Kaya, Aksu Ayse Esra, Karapınar Tekden, Saracoglu Zeynep Nurhan

机构信息

Department of Dermatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey.

Deparrment of Dermatology, Istanbul Training and Research Hospital, Istanbul, Turkey.

出版信息

An Bras Dermatol. 2018 Jan-Feb;93(1):33-38. doi: 10.1590/abd1806-4841.20185468.

Abstract

BACKGROUND

While phototherapy is a well-established treatment for many dermatoses, data from the literature regarding its use in elderly patients are quite limited.

OBJECTIVE

In this study, we aimed to determine the phototherapy indications in geriatric patients and to evaluate the effectiveness and reliability of phototherapy in this group.

METHODS

This study included 95 patients of 65 years of age and older who were treated in our phototherapy unit between 2006 and 2015. The data for this study were collected retrospectively from patient follow-up forms in the phototherapy unit.

RESULTS

Phototherapy was administered to 28 (29.5%) patients for mycosis fungoides, 25 (26.3%) patients foplaque type psoriasis, 12 (12.6%) patients for palmoplantar psoriasis, 12 (12.6%) patients for generalized pruritus, and 18 (19%) for other dermatoses. Of the patients, 64.2% had received a narrowband UVB (NB-UVB), 21.1% oral psoralen UVA (PUVA), and 14.7% local PUVA treatment. A complete response was achieved in 76.9-85.7% of the mycosis fungoides and in 73.71-100% of the psoriasis vulgaris patients treated with NB-UVB and PUVA, respectively. All the patients with generalized pruritus were treated with NB-UVB, and 80% of these patients achieved significant improvement. The erythema rate was found to be 0.43% per session for NB-UVB treatment and 0.46% per session for PUVA treatment as a side effect.

STUDY LIMITATIONS

The limitations of our study are that it was retrospective and the remission durations of the patients are not known.

CONCLUSION

This study showed that phototherapy is effective and reliable in the elderly population with proper dose increases and close follow-up.

摘要

背景

虽然光疗是治疗多种皮肤病的成熟方法,但文献中关于其在老年患者中的应用数据相当有限。

目的

在本研究中,我们旨在确定老年患者的光疗适应症,并评估该组患者光疗的有效性和可靠性。

方法

本研究纳入了2006年至2015年间在我们光疗科接受治疗的95例65岁及以上的患者。本研究的数据是从光疗科的患者随访表中回顾性收集的。

结果

28例(29.5%)蕈样肉芽肿患者、25例(26.3%)斑块型银屑病患者、12例(12.6%)掌跖银屑病患者、12例(12.6%)全身性瘙痒患者以及18例(19%)其他皮肤病患者接受了光疗。患者中,64.2%接受了窄谱中波紫外线(NB-UVB)治疗,21.1%接受了口服补骨脂素联合长波紫外线(PUVA)治疗,14.7%接受了局部PUVA治疗。分别接受NB-UVB和PUVA治疗的蕈样肉芽肿患者中,76.9%-85.7%获得了完全缓解,寻常型银屑病患者中73.71%-100%获得了完全缓解。所有全身性瘙痒患者均接受NB-UVB治疗,其中80%的患者有显著改善。NB-UVB治疗的红斑发生率为每次治疗0.43%,PUVA治疗为每次治疗0.46%,均为副作用。

研究局限性

我们研究的局限性在于它是回顾性的,且患者的缓解持续时间未知。

结论

本研究表明,在老年人群中,适当增加剂量并密切随访,光疗是有效且可靠的。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验