Bulur Isil, Erdogan Hilal Kaya, Aksu Ayse Esra, Karapınar Tekden, Saracoglu Zeynep Nurhan
Department of Dermatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey.
Deparrment of Dermatology, Istanbul Training and Research Hospital, Istanbul, Turkey.
An Bras Dermatol. 2018 Jan-Feb;93(1):33-38. doi: 10.1590/abd1806-4841.20185468.
While phototherapy is a well-established treatment for many dermatoses, data from the literature regarding its use in elderly patients are quite limited.
In this study, we aimed to determine the phototherapy indications in geriatric patients and to evaluate the effectiveness and reliability of phototherapy in this group.
This study included 95 patients of 65 years of age and older who were treated in our phototherapy unit between 2006 and 2015. The data for this study were collected retrospectively from patient follow-up forms in the phototherapy unit.
Phototherapy was administered to 28 (29.5%) patients for mycosis fungoides, 25 (26.3%) patients foplaque type psoriasis, 12 (12.6%) patients for palmoplantar psoriasis, 12 (12.6%) patients for generalized pruritus, and 18 (19%) for other dermatoses. Of the patients, 64.2% had received a narrowband UVB (NB-UVB), 21.1% oral psoralen UVA (PUVA), and 14.7% local PUVA treatment. A complete response was achieved in 76.9-85.7% of the mycosis fungoides and in 73.71-100% of the psoriasis vulgaris patients treated with NB-UVB and PUVA, respectively. All the patients with generalized pruritus were treated with NB-UVB, and 80% of these patients achieved significant improvement. The erythema rate was found to be 0.43% per session for NB-UVB treatment and 0.46% per session for PUVA treatment as a side effect.
The limitations of our study are that it was retrospective and the remission durations of the patients are not known.
This study showed that phototherapy is effective and reliable in the elderly population with proper dose increases and close follow-up.
虽然光疗是治疗多种皮肤病的成熟方法,但文献中关于其在老年患者中的应用数据相当有限。
在本研究中,我们旨在确定老年患者的光疗适应症,并评估该组患者光疗的有效性和可靠性。
本研究纳入了2006年至2015年间在我们光疗科接受治疗的95例65岁及以上的患者。本研究的数据是从光疗科的患者随访表中回顾性收集的。
28例(29.5%)蕈样肉芽肿患者、25例(26.3%)斑块型银屑病患者、12例(12.6%)掌跖银屑病患者、12例(12.6%)全身性瘙痒患者以及18例(19%)其他皮肤病患者接受了光疗。患者中,64.2%接受了窄谱中波紫外线(NB-UVB)治疗,21.1%接受了口服补骨脂素联合长波紫外线(PUVA)治疗,14.7%接受了局部PUVA治疗。分别接受NB-UVB和PUVA治疗的蕈样肉芽肿患者中,76.9%-85.7%获得了完全缓解,寻常型银屑病患者中73.71%-100%获得了完全缓解。所有全身性瘙痒患者均接受NB-UVB治疗,其中80%的患者有显著改善。NB-UVB治疗的红斑发生率为每次治疗0.43%,PUVA治疗为每次治疗0.46%,均为副作用。
我们研究的局限性在于它是回顾性的,且患者的缓解持续时间未知。
本研究表明,在老年人群中,适当增加剂量并密切随访,光疗是有效且可靠的。