PathSTORM：早期癌症检测之路。

PathSTORM: a road to early cancer detection.

作者信息

Troy Kris, Liu Yang, Hainer Sarah J

机构信息

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Mol Cell Oncol. 2020 Jun 21;7(5):1776086. doi: 10.1080/23723556.2020.1776086. eCollection 2020.

DOI:10.1080/23723556.2020.1776086

PMID:32944634

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469673/

Abstract

Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

摘要

染色质结构的破坏可能通过促进恶性转化而引发早期致癌作用。利用针对病理组织优化的随机光学重建显微镜（PathSTORM），我们发现了在致癌作用的各个进展阶段高阶染色质折叠逐渐解压缩的现象。我们证明了对传统病理学不易察觉的癌前基因组结构具有潜在的检测能力。