手性钯催化不对称氢化合成 α,α-二氟-β-芳基丁酸酯
Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation.
机构信息
Chang-Kung Chuang Institute and Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China.
出版信息
Org Lett. 2020 Oct 2;22(19):7508-7512. doi: 10.1021/acs.orglett.0c02700. Epub 2020 Sep 18.
Synthesis of optically active -difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed asymmetric hydrogenation.
由于在制药和农用化学品领域的独特性质，光学活性 - 二氟有机分子的合吸引了大量关注。在此，通过钯催化的不对称氢化反应，以高收率（83-99%）和中等至优异的对映选择性（≤97:3 er）制备了一系列对映体富集的α，α-二氟-β-芳基丁酸酯。
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