Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Department of Chemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY 10065, USA.
Chem Commun (Camb). 2020 Oct 20;56(83):12608-12611. doi: 10.1039/d0cc05494a.
Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET).
合成叶绿素不仅具有荧光性，还可以通过调节四吡咯系统螯合金属离子。在其吡咯环上连接连接子可以实现与生物分子的共轭，从而产生靶向特异性。通过改变这些化学-光物理性质，本工作促进了叶绿素在荧光成像和正电子发射断层扫描（PET）中的应用。
