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Fluorinated porphyrinoids as efficient platforms for new photonic materials, sensors, and therapeutics.氟化卟啉作为新型光子材料、传感器和治疗剂的有效平台。
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Glycosylated Porphyrins, Phthalocyanines, and Other Porphyrinoids for Diagnostics and Therapeutics.用于诊断和治疗的糖基化卟啉、酞菁及其他卟啉类化合物
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Photodynamic inactivation of bioluminescent Escherichia coli by neutral and cationic pyrrolidine-fused chlorins and isobacteriochlorins.中性和阳离子吡咯烷稠合二氢卟吩及异菌叶绿素对生物发光大肠杆菌的光动力灭活作用
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通过一系列点击反应轻松合成二氢卟吩生物共轭物。

Facile synthesis of chlorin bioconjugates by a series of click reactions.

作者信息

Gonzales Junior, Bhupathiraju N V S Dinesh K, Perea William, Chu Huong, Berisha Naxhije, Bueno Veronica, Dodic Naser, Rozenberg Julia, Greenbaum Nancy L, Drain Charles Michael

机构信息

Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA.

出版信息

Chem Commun (Camb). 2017 Mar 28;53(26):3773-3776. doi: 10.1039/c7cc01265a.

DOI:10.1039/c7cc01265a
PMID:28304032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5463999/
Abstract

A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.

摘要

一个连接有四个短聚乙二醇和一个羧酸盐连接基的多功能二氢卟吩平台能够快速与生物靶向基序(如蛋白质和寡核苷酸)结合。二氢卟吩的稳定性和光物理性质有助于开发诊断、成像、分子追踪和诊疗技术。