Plant Science Research Laboratory (LRSV), UMR5546 CNRS/Université Toulouse 3, 24 chemin de Borde Rouge, Auzeville-Tolosane, France.
J Exp Bot. 2021 Mar 17;72(6):2071-2082. doi: 10.1093/jxb/eraa441.
Organisms need to deal with the absolute requirement for metals and also their possible toxicity. This is achieved through an intricate network of signaling pathways that are integrated to ultimately fine-tune iron uptake and metabolism. The mechanisms by which plants cope with iron limitation and the associated genomic responses are well characterized. On top of this transcriptional cascade is another level of regulation involving the post-translational protein modification and degradation. The ubiquitination and/or degradation of several transcription factors in the iron-deficiency signaling pathways and metal transporters has recently come to light. In this review we discuss the mechanisms and possible roles of protein modification and turnover in the regulation of root iron-deficiency responses. We also highlight the tight coupling between metal sensing by E3 ubiquitin ligases or bifunctional transporters and protein degradation.
生物体需要应对对金属的绝对需求以及它们可能的毒性。这是通过一个复杂的信号通路网络来实现的，这些信号通路被整合在一起，最终精细地调节铁的摄取和代谢。植物应对铁限制和相关基因组反应的机制已经得到很好的描述。在这个转录级联之上，还有另一个涉及翻译后蛋白质修饰和降解的调节层次。最近，铁饥饿信号通路和金属转运体中的几种转录因子的泛素化和/或降解已经被揭示。在这篇综述中，我们讨论了蛋白质修饰和周转在调控根缺铁反应中的机制和可能作用。我们还强调了 E3 泛素连接酶或双功能转运体对金属的感应与蛋白质降解之间的紧密耦合。
