Zlosnik James E A, Henry Deborah A, Hird Trevor J, Hickman Rebecca, Campbell Maureen, Cabrera Adriana, Laino Chiavegatti Giulio, Chilvers Mark A, Sadarangani Manish
Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine.
Healthy Starts Theme, and.
Ann Am Thorac Soc. 2020 Dec;17(12):1549-1557. doi: 10.1513/AnnalsATS.201906-443OC.
Infections by species bacteria in cystic fibrosis (CF) may be transmissible, necessitating infection control measures, and remain a serious cause of morbidity and mortality. The last major study of epidemiology in Canada included cases up until July 2000 and was marked by the dominance of a limited number of epidemic clones of . Describe the nationwide epidemiology of species infections in people with cystic fibrosis in Canada over the 17-year period since 2000. Isolates were collected from across Canada between August 2000 and July 2017 and identified to the species and, for isolates between 2015 and 2017, strain level. We analyzed 1,362 isolates from at least 396 people with CF. Forty-nine percent ( = 666) of all isolates and 47% ( = 179) of new incident infections were identified as . The incidence of infection in the Canadian CF population did not change between 2000 and 2017 at 6 cases per 1,000 annually. Multilocus sequence typing analysis suggested minimal sharing of clones in Canada. The epidemiology of in CF in Canada has shifted from limited numbers of epidemic strains of to largely nonclonal isolates of , , and other species. Despite widespread infection control, however, species bacteria continue to be acquired by people with CF at an unchanged rate, posing a continued hazard.
囊性纤维化（CF）患者感染某些细菌可能具有传染性，因此需要采取感染控制措施，而且这些感染仍是发病和死亡的严重原因。加拿大上一次关于该疾病流行病学的主要研究涵盖截至2000年7月的病例，其特点是少数几种流行克隆菌株占主导地位。描述2000年以来17年间加拿大囊性纤维化患者中某些细菌感染的全国性流行病学情况。在2000年8月至2017年7月期间从加拿大各地收集分离株，并鉴定到种水平，对于2015年至2017年的分离株，鉴定到菌株水平。我们分析了至少396名囊性纤维化患者的1362株分离株。所有分离株的49%（n = 666）和新发病例感染的47%（n = 179）被鉴定为[具体细菌名称未给出]。2000年至2017年期间，加拿大囊性纤维化人群中[具体细菌名称未给出]感染的发病率保持在每年每1000人6例不变。多位点序列分型分析表明加拿大的克隆菌株共享极少。加拿大囊性纤维化患者中[具体细菌名称未给出]的流行病学已从少数几种流行菌株转变为主要是[具体细菌名称未给出]、[具体细菌名称未给出]和其他菌种的非克隆分离株。然而，尽管广泛采取了感染控制措施，囊性纤维化患者感染某些细菌的比例仍未改变，持续构成威胁。
