Speert David P, Henry Deborah, Vandamme Peter, Corey Mary, Mahenthiralingam Eshwar
University of British Columbia and Children's and Women's Health Centre of British Columbia, Vancouver, Canada.
Emerg Infect Dis. 2002 Feb;8(2):181-7. doi: 10.3201/eid0802.010163.
The Burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (CF). Although evidence for patient-to-patient spread is clear, microbial factors facilitating transmission are poorly understood. To identify microbial clones with enhanced transmissibility, we evaluated B. cepacia complex isolates from patients with CF from throughout Canada. A total of 905 isolates from the B. cepacia complex were recovered from 447 patients in 8 of the 10 provinces; 369 (83%) of these patients had genomovar III and 43 (9.6%) had B. multivorans (genomovar II). Infection prevalence differed substantially by region (22% of patients in Ontario vs. 5% in Quebec). Results of typing by random amplified polymorphic DNA analysis or pulsed-field gel electrophoresis indicated that strains of B. cepacia complex from genomovar III are the most potentially transmissible and that the B. cepacia epidemic strain marker is a robust marker for transmissibility.
洋葱伯克霍尔德菌复合体是囊性纤维化（CF）患者中的一组重要病原体。尽管患者之间传播的证据确凿，但促进传播的微生物因素却知之甚少。为了鉴定具有增强传播能力的微生物克隆，我们评估了来自加拿大各地CF患者的洋葱伯克霍尔德菌复合体分离株。从10个省中的8个省的447名患者中总共分离出905株洋葱伯克霍尔德菌复合体；这些患者中369例（83%）为基因变种III，43例（9.6%）为多食伯克霍尔德菌（基因变种II）。感染率因地区而异（安大略省22%的患者，魁北克省为5%）。随机扩增多态性DNA分析或脉冲场凝胶电泳分型结果表明，基因变种III的洋葱伯克霍尔德菌复合体菌株最具潜在传播能力，且洋葱伯克霍尔德菌流行菌株标记是传播能力的可靠标记。
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