Ophthalmology Department, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Psychiatry Department, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.
Ocul Immunol Inflamm. 2022 Feb 17;30(2):428-432. doi: 10.1080/09273948.2020.1800052. Epub 2020 Sep 18.
To evaluate choroidal vascularity index (CVI) and to investigate the association of CVI with neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in obsessive-compulsive disorder (OCD).
This prospective study included newly diagnosed OCD patients and healthy controls. All patients underwent EDI-OCT imaging to assess the subfoveal choroidal thickness (sCT) and peripapillary CT (pCT). CVI was defined as the ratio of luminal area to stromal area after binarization on EDI-OCT images.
A total of 39 patients with OCD and 25 controls were included. The sCT, pCT, and CVI values were significantly higher in the OCD vs. control group (˂0.05 for all). The NLR values were significantly higher in the OCD vs. control group ( = .007). A significant positive correlation was noted between CVI and NLR ( = .039).
Our findings suggest that systemic inflammation may play a role in the pathogenesis of OCD.
评估脉络膜血管指数（CVI），并研究 CVI 与中性粒细胞与淋巴细胞比值（NLR）的相关性，NLR 是炎症的指标，用于强迫症（OCD）。
本前瞻性研究纳入了新诊断的 OCD 患者和健康对照者。所有患者均接受 EDI-OCT 成像，以评估中心凹下脉络膜厚度（sCT）和视盘周围 CT（pCT）。CVI 通过 EDI-OCT 图像二值化后，定义为管腔面积与基质面积的比值。
共纳入 39 例 OCD 患者和 25 例对照者。OCD 组的 sCT、pCT 和 CVI 值明显高于对照组（均 ˂0.05）。OCD 组的 NLR 值明显高于对照组（ = 0.007）。CVI 与 NLR 呈显著正相关（ = 0.039）。
我们的研究结果表明，全身炎症可能在 OCD 的发病机制中起作用。
