Khalafallah Adham M, Jimenez Adrian E, Romo Carlos G, Kamson David Olayinka, Kleinberg Lawrence, Weingart Jon, Brem Henry, Grossman Stuart A, Mukherjee Debraj
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore.
2Department of Neurology, Brain Cancer Program, Johns Hopkins University School of Medicine, Baltimore.
J Neurosurg. 2020 Sep 18;135(1):87-92. doi: 10.3171/2020.5.JNS201299. Print 2021 Jul 1.
There has been limited research on the efficacy of multidisciplinary tumor boards (MDTBs) in improving the treatment of patients with tumors affecting the nervous system. The objective of the present study was to quantify the utility of MDTBs in providing alternative diagnostic interpretations and treatment plans for this patient population.
The authors performed a prospective study of patients in 4 hospitals whose cases were discussed at MDTBs between July and November 2019. Patient demographic data, diagnoses, treatment plans, and eligibility for clinical trials were recorded, among other variables.
A total of 176 cases met eligibility criteria for study inclusion. The majority (53%) of patients were male, and the mean patient age was 52 years. The most frequent diagnosis was glioblastoma (32.4%). Among the evaluable cases, MDTBs led to 38 (21.6%) changes in image interpretation and 103 (58.2%) changes in patient management. Additionally, patients whose cases were discussed at MDTBs had significantly shorter referral times than patients whose cases were not discussed (p = 0.024).
MDTB discussions led to significant numbers of diagnostic and treatment plan changes as well as shortened referral times, highlighting the potential clinical impact of multidisciplinary care for patients with nervous system tumors.
关于多学科肿瘤委员会（MDTBs）在改善神经系统肿瘤患者治疗效果方面的研究有限。本研究的目的是量化MDTBs在为该患者群体提供替代诊断解读和治疗方案方面的效用。
作者对2019年7月至11月期间在MDTBs上讨论病例的4家医院的患者进行了一项前瞻性研究。记录了患者的人口统计学数据、诊断、治疗方案以及临床试验资格等变量。
共有176例病例符合研究纳入的资格标准。大多数（53%）患者为男性，患者平均年龄为52岁。最常见的诊断是胶质母细胞瘤（32.4%）。在可评估的病例中，MDTBs导致38例（21.6%）影像解读改变和103例（58.2%）患者管理改变。此外，在MDTBs上讨论病例的患者的转诊时间明显短于未讨论病例的患者（p = 0.024）。
MDTBs讨论导致大量诊断和治疗方案改变以及转诊时间缩短，突出了多学科护理对神经系统肿瘤患者的潜在临床影响。
