Department of Anesthesiology, Quanzhou First Hospital.
Department of Anesthesiology, Quanzhou Hospital of Traditional Chinese Medicine, Quanzhou.
Clin Neuropharmacol. 2020 Sep/Oct;43(5):134-138. doi: 10.1097/WNF.0000000000000410.
Nalbuphine and dexmedetomidine are both used as anesthesia adjuvants for brachial plexus block, but their efficacy and safety in younger patients are not clear. In this study, we aimed to compare the efficacy and side effects of these 2 drugs in young patients undergoing brachial plexus block.
We recruited 48 young patients aged 18 to 30 years requiring supraclavicular brachial plexus block. Subjects were randomly divided into 2 groups. Patients in group levobupivacaine+nalbuphine received 28 mL of 0.5% levobupivacaine and 10 mg of nalbuphine diluted in 2 mL 0.9% saline. Patients in group levobupivacaine+dexmedetomidine (LD) received 28 mL of 0.5% levobupivacaine and 0.75 μg/kg dexmedetomidine diluted in 2 mL 0.9% saline. Demographic information, types of fracture, onset time of motor and sensory blocks, duration of block, side effects, and analgesic use were recorded.
We found that the 2 groups did not differ significantly in the demographic profile and fracture type. Compared with group LD, group LD had significantly shorter sensory and motor block onset time, longer block duration, less analgesic need, and less side effects.
In summary, our study suggests that nalbuphine is a better anesthesia adjuvant for supraclavicular brachial plexus block in young patients.
纳布啡和右美托咪定均可作为臂丛神经阻滞的麻醉辅助剂，但在年轻患者中的疗效和安全性尚不清楚。本研究旨在比较这两种药物在年轻患者行臂丛神经阻滞中的疗效和副作用。
我们招募了 48 例年龄在 18 至 30 岁之间需要行锁骨上臂丛神经阻滞的年轻患者。将患者随机分为两组。在布比卡因+纳布啡组（L+N 组）中，患者接受 28 mL 0.5%布比卡因和 10 mg 纳布啡稀释于 2 mL 0.9%生理盐水。在布比卡因+右美托咪定组（L+D 组）中，患者接受 28 mL 0.5%布比卡因和 0.75 μg/kg 右美托咪定稀释于 2 mL 0.9%生理盐水。记录患者的人口统计学资料、骨折类型、运动和感觉阻滞的起效时间、阻滞持续时间、副作用和镇痛药使用情况。
我们发现两组患者在人口统计学特征和骨折类型方面无显著差异。与 L+D 组相比，L+N 组的感觉和运动阻滞起效时间更短、阻滞持续时间更长、镇痛药需求更少、副作用更少。
总之，我们的研究表明，纳布啡是年轻患者锁骨上臂丛神经阻滞的更好麻醉辅助剂。
