Department of Zoology, Central University of Punjab, Bathinda 151 001, Punjab, India.
Department of Radiotherapy, Advanced Cancer Institute, Bathinda affiliated with Baba Farid University of Health Sciences, Faridkot 151 203, Punjab, India.
Int J Mol Sci. 2020 Sep 16;21(18):6787. doi: 10.3390/ijms21186787.
Intrinsic resistance to ionizing radiation is the major impediment in the treatment and clinical management of esophageal squamous cell carcinoma (ESCC), leading to tumor relapse and poor prognosis. Although several biological and molecular mechanisms are responsible for resistance to radiotherapy in ESCC, the molecule(s) involved in predicting radiotherapy response and prognosis are still lacking, thus requiring a detailed understanding. Recent studies have demonstrated an imperative correlation amongst several long non-coding RNAs and their involvement in complex cellular networks like DNA damage and repair, cell cycle, apoptosis, proliferation, and epithelial-mesenchymal transition. Additionally, accumulating evidence has suggested abnormal expression of lncRNAs in malignant tumor cells before and after radiotherapy effects in tumor cells' sensitivity. Thus, lncRNAs indeed represent unique molecules that can influence tumor cell susceptibility for various clinical interventions. On this note, herein, we have summarized the current status of lncRNAs in augmenting resistance/sensitivity in ESCC against radiotherapy. In addition, we have also discussed various strategies to increase the radiosensitivity in ESCC cells under clinical settings.
内在的电离辐射抗性是食管鳞癌 (ESCC) 治疗和临床管理的主要障碍，导致肿瘤复发和预后不良。尽管有几种生物学和分子机制导致 ESCC 对放射治疗的抗性，但仍缺乏参与预测放射治疗反应和预后的分子，因此需要详细了解。最近的研究表明，几种长链非编码 RNA 之间存在着至关重要的相关性，它们参与了复杂的细胞网络，如 DNA 损伤和修复、细胞周期、细胞凋亡、增殖和上皮-间充质转化。此外，越来越多的证据表明，lncRNAs 在肿瘤细胞对放射治疗的敏感性前后在恶性肿瘤细胞中的异常表达。因此，lncRNAs 确实代表了独特的分子，可以影响肿瘤细胞对各种临床干预的易感性。在这一点上，我们在这里总结了 lncRNAs 在增强 ESCC 对放射治疗的抗性/敏感性方面的最新进展。此外，我们还讨论了在临床环境下增加 ESCC 细胞放射敏感性的各种策略。
