Department of Neurosurgery, Linyi People's Hospital, Linyi, 276003, Shandong Province, China.
Department of Neurology, Linyi People's Hospital, Linyi, 276003, Shandong Province, China.
BMC Neurol. 2020 Sep 18;20(1):351. doi: 10.1186/s12883-020-01847-5.
Oculomotor nerve palsy (ONP) is a common symptom of posterior communicating artery aneurysm (PcomAA) that can lead to impaired eye movement and pupil dilation. Currently, surgical clipping and endovascular embolization are the two most popular treatment methods for PcomAA-induced ONP; however, the recovery outcome between the two methods remains to be elucidated.
In the present study, we thoroughly compared the pretreatment factors and recovery outcome of the two treatments on 70 patients with PcomAA-induced ONP. The patients were separated into two groups based on the treatment that was received. Pretreatment factors, including age, sex, time period between ONP onset and treatment, ONP type, aneurysm diameter, status of subarachnoid hemorrhage and aneurysm rupture were recorded for each individual patient. Recovery outcome of the patients was assessed over a 12-month period.
No significant differences were observed in any of the analyzed factors. Importantly, we revealed a significantly higher full recovery rate for the patients receiving the surgical clipping treatment than the ones that received the endovascular embolization treatment. In addition, we showed that patients' age was negatively correlated with the recovery extent in both treatment groups.
The outcome of our study suggests that surgical clipping might be a better option to treat PcomAA-induced ONP.
动眼神经麻痹（ONP）是后交通动脉瘤（PcomAA）的常见症状，可导致眼球运动和瞳孔扩张受损。目前，手术夹闭和血管内栓塞是治疗 PcomAA 引起的 ONP 的两种最常用的方法；然而，这两种方法的恢复结果仍有待阐明。
在本研究中，我们对 70 例 PcomAA 引起的 ONP 患者的两种治疗方法的预处理因素和恢复结果进行了全面比较。根据所接受的治疗，将患者分为两组。记录每位患者的预处理因素，包括年龄、性别、ONP 发病与治疗之间的时间间隔、ONP 类型、动脉瘤直径、蛛网膜下腔出血和动脉瘤破裂的情况。对患者的恢复结果进行了 12 个月的评估。
在分析的因素中没有观察到显著差异。重要的是，我们发现接受手术夹闭治疗的患者的完全恢复率明显高于接受血管内栓塞治疗的患者。此外，我们还表明，在两种治疗组中，患者的年龄与恢复程度呈负相关。
我们的研究结果表明，手术夹闭可能是治疗 PcomAA 引起的 ONP 的更好选择。
