Division of Pulmonology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Division of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Int J Clin Pract. 2021 Mar;75(3):e13720. doi: 10.1111/ijcp.13720. Epub 2020 Oct 13.
The impact of serum uric acid (SUA) on atherosclerosis has been suspected to be epiphenomenal owing to its close relationship with metabolic abnormalities. The aim of the present study was to evaluate the association between SUA levels and arterial stiffness in the absence of established cardiovascular (CV) disorders.
The relationship between SUA levels and brachial-ankle pulse wave velocity (baPWV) was examined in 353 asymptomatic adults (57 ± 8 years, 11.9% men) without established CV disorders defined as systolic blood pressure (BP) ≥140 mmHg or diastolic BP ≥ 90 mmHg; total cholesterol ≥240 mg/dL; low-density lipoprotein cholesterol ≥160 mg/dL; high-density lipoprotein cholesterol <40 mg/dL; fasting glucose ≥126 mg/dL; body mass index ≥25.0 kg/m ; current smoking; and history of medication for hypertension, diabetes, and dyslipidemia. Subjects were stratified into four groups based on the quartiles of their SUA levels.
Mean baPWV was significantly different in all groups: group I, 1320 ± 195 cm/s; group II, 1336 ± 195 cm/s; group III, 1404 ± 199 cm/s; and group IV, 1483 ± 248 cm/s (P < .001). SUA levels were significantly correlated with baPWV (r = .364) (P < .001). Multivariate linear regression analysis showed that SUA (β: 32.93; 95% confidence interval [CI]: 18.99-54.87), together with age (β: 11.44; 95% CI: 9.36-13.53) and systolic BP (β: 8.98; 95% CI: 6.80-11.16), was significantly associated with baPWV (P < .001).
High SUA levels have an independent association with increased arterial stiffness even in subjects without established CV disorders.
由于血清尿酸（SUA）与代谢异常密切相关，因此其对动脉粥样硬化的影响可能只是一种偶然现象。本研究旨在评估在无明确心血管疾病（CV）的情况下，SUA 水平与动脉僵硬度之间的关系。
本研究共纳入 353 例无明确 CV 疾病的无症状成年人（57±8 岁，11.9%为男性），其定义为收缩压（BP）≥140mmHg 或舒张压≥90mmHg；总胆固醇≥240mg/dL；低密度脂蛋白胆固醇≥160mg/dL；高密度脂蛋白胆固醇<40mg/dL；空腹血糖≥126mg/dL；体重指数≥25.0kg/m2；当前吸烟；以及正在服用治疗高血压、糖尿病和血脂异常的药物。根据 SUA 水平的四分位数将受试者分为四组。
所有组的平均 baPWV 均有显著差异：第 1 组，1320±195cm/s；第 2 组，1336±195cm/s；第 3 组，1404±199cm/s；第 4 组，1483±248cm/s（P<0.001）。SUA 水平与 baPWV 呈显著相关（r=0.364）（P<0.001）。多元线性回归分析显示，SUA（β：32.93；95%置信区间[CI]：18.99-54.87）与年龄（β：11.44；95%CI：9.36-13.53）和收缩压（β：8.98；95%CI：6.80-11.16）共同与 baPWV 显著相关（P<0.001）。
即使在无明确 CV 疾病的患者中，高 SUA 水平与动脉僵硬度的增加也有独立的关联。
