Hwang Jiwon, Hwang Jung Hye, Chung Sun Mi, Kwon Min-Jung, Ahn Joong Kyong
Department of Internal Medicine, National Police Hospital Centre for Health Promotion, Samsung Medical Centre Department of Laboratory Medicine Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Medicine (Baltimore). 2018 Sep;97(36):e12086. doi: 10.1097/MD.0000000000012086.
We investigated the association between serum uric acid (SUA) and brachial ankle pulse wave velocity (baPWV) in an apparently healthy population. We performed a cross-sectional study on middle-aged Koreans who completed a yearly health-screening program between January and December 2014. Subjects with coronary artery disease, diabetes, or hypertension were excluded. Linear regression analyses were used to study the relationship between SUA and baPWV. Multiple adjustments were made for variables based on clinical or statistical significance. Of 66,917 study participants (38,170 men and 28,747 women), the mean age was 39.4 ± 6.7 years and the average SUA level was 5.23 ± 1.4 mg/dL. SUA values were higher in men than in women (6.1 ± 1.2 mg/dL vs. 4.1 ± 0.8 mg/dL). SUA was linearly associated with baPWV in women and in men (P < .001, respectively). Multiple regression analyses remained significant for women with a positive association with baPWV across SUA quintiles in a dose-response manner (P < .001) while no longer for men with a J-shaped association between SUA quintiles and baPWV. When SUA modeled continuously, baPWV rose by 12.413 cm/s in women (P < .001) and by 6.588 cm/s in men (P < .001) for each 1 mg/dL increase of SUA. In a low-risk, middle-aged, large Korean population, higher SUA levels could have an unfavorable impact on arterial stiffness as measured by baPWV, and this association was stronger in women than in men.
我们在一个看似健康的人群中研究了血清尿酸（SUA）与肱踝脉搏波速度（baPWV）之间的关联。我们对2014年1月至12月期间完成年度健康筛查项目的中年韩国人进行了一项横断面研究。排除患有冠状动脉疾病、糖尿病或高血压的受试者。采用线性回归分析来研究SUA与baPWV之间的关系。基于临床或统计学意义对变量进行了多重调整。在66917名研究参与者（38170名男性和28747名女性）中，平均年龄为39.4±6.7岁，平均SUA水平为5.23±1.4mg/dL。男性的SUA值高于女性（6.1±1.2mg/dL对4.1±0.8mg/dL）。SUA与女性和男性的baPWV均呈线性相关（P均<0.001）。多元回归分析显示，女性中SUA五分位数与baPWV呈剂量反应关系的正相关仍然显著（P<0.001），而男性中SUA五分位数与baPWV呈J形关联则不再显著。当SUA连续建模时，SUA每增加1mg/dL，女性的baPWV升高12.413cm/s（P<0.001），男性升高6.588cm/s（P<0.001）。在一个低风险、中年、韩国大样本人群中，较高的SUA水平可能会对通过baPWV测量的动脉僵硬度产生不利影响，且这种关联在女性中比在男性中更强。
