格林-巴利综合征中糖皮质激素受体基因多态性。
Glucocorticoid receptor gene polymorphisms in Guillain-Barré syndrome.
机构信息
Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh; Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore 7408, Bangladesh.
Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh.
出版信息
J Neuroimmunol. 2020 Nov 15;348:577388. doi: 10.1016/j.jneuroim.2020.577388. Epub 2020 Sep 9.
Guillain-Barré syndrome (GBS) is an immune-mediated paralytic disorder. Glucocorticoid receptor (GR) gene polymorphisms affect the sensitivity to glucocorticoids and have been related to microbial colonization and infection, and thereby may influence susceptibility to GBS. The associations between GR polymorphisms (ER22/23EK, N363S, BclI, TthIII-1 and GR-9beta) and development of GBS were investigated in 151 patients and 151 healthy controls. GR polymorphisms or haplotypes were not associated with GBS susceptibility. Haplotype 1 (TthIII-1[T/T]:BclI[G/G]:GR-9beta[A/A]) was less common in GBS; but not statistically significant after correction (P = 0.021; Pc = 0.108). The GR-9beta(G/A) and TthIII-1(C/T) genotypes were frequent in anti-GM1-antibody-positive patients than anti-GM1-antibody-negative patients (P = 0.017 and P = 0.030, respectively).
格林-巴利综合征（GBS）是一种免疫介导的瘫痪性疾病。糖皮质激素受体（GR）基因多态性影响糖皮质激素的敏感性，并与微生物定植和感染有关，因此可能影响 GBS 的易感性。在 151 名患者和 151 名健康对照中研究了 GR 多态性（ER22/23EK、N363S、BclI、TthIII-1 和 GR-9β）与 GBS 发展之间的关系。GR 多态性或单倍型与 GBS 易感性无关。单倍型 1（TthIII-1[T/T]：BclI[G/G]：GR-9β[A/A]）在 GBS 中较少见；但校正后无统计学意义（P=0.021；Pc=0.108）。与抗 GM1 抗体阴性患者相比，抗 GM1 抗体阳性患者中 GR-9β（G/A）和 TthIII-1（C/T）基因型更为常见（P=0.017 和 P=0.030）。
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