Cappuccio F P, Markandu N D, Singer D R, Smith S J, Shore A C, MacGregor G A
J Hypertens. 1987 Feb;5(1):67-71. doi: 10.1097/00004872-198702000-00010.
Eighteen unselected patients with untreated mild to moderate essential hypertension, whose average supine blood pressure after 2 months' observation on no treatment was 154/103 mmHg, were entered into a double-blind randomized crossover study of 1 month's treatment with calcium lactate gluconate (40 mmol of elemental calcium/day) and treatment with placebo for a further month. Despite a significant increase in total plasma calcium (P less than 0.01) and in 24-h urinary excretion of calcium (P less than 0.025) while taking calcium lactate gluconate, there was no fall in blood pressure with calcium supplementation compared to treatment with placebo.
18例未经选择的轻度至中度原发性高血压患者，在未治疗观察2个月后平均仰卧血压为154/103 mmHg，进入一项双盲随机交叉研究，接受1个月的葡萄糖酸钙乳酸盐治疗（元素钙40 mmol/天），随后再接受1个月的安慰剂治疗。尽管服用葡萄糖酸钙乳酸盐时总血浆钙显著升高（P<0.01），24小时尿钙排泄量也显著增加（P<0.025），但与安慰剂治疗相比，补充钙并未使血压下降。
