Cappuccio F P, Markandu N D, Beynon G W, Shore A C, Sampson B, MacGregor G A
Br Med J (Clin Res Ed). 1985 Jul 27;291(6490):235-8. doi: 10.1136/bmj.291.6490.235.
Seventeen unselected patients with mild to moderate essential hypertension and whose average supine blood pressure after two months' observation with no treatment was 154/100 mm Hg were entered into a double blind randomised crossover study of one month's treatment with magnesium aspartate (15 mmol magnesium/day) and treatment with placebo for a further month. This preparation of magnesium was well tolerated and did not cause diarrhoea. Despite a significant increase in plasma magnesium concentration and a significant increase in urinary excretion of magnesium while taking magnesium aspartate there was no fall in blood pressure compared with either treatment with placebo or values before treatment. The results provide no evidence for a role of dietary magnesium in the regulation of high blood pressure and are contrary to recent speculations.
17名未经挑选的轻度至中度原发性高血压患者，在未经治疗观察两个月后平均仰卧血压为154/100毫米汞柱，他们进入了一项双盲随机交叉研究，接受为期一个月的天冬氨酸镁治疗（15毫摩尔镁/天），随后再接受为期一个月的安慰剂治疗。这种镁制剂耐受性良好，未引起腹泻。尽管服用天冬氨酸镁时血浆镁浓度显著升高，尿镁排泄量也显著增加，但与安慰剂治疗或治疗前的值相比，血压并未下降。这些结果没有为膳食镁在高血压调节中的作用提供证据，并且与最近的推测相反。
