Laboratório de investigação em nutrição clínica e exercício (Labince), Faculdade de Nutrição, Universidade Federal de Goiás (UFG), Goiânia, GO, 74605-080, Brazil.
Departamento de Nefrologia, Universidade Federal de São Paulo e Fundação Oswaldo Ramos, São Paulo, SP, 04021-001, Brazil.
Complement Ther Med. 2020 Aug;52:102479. doi: 10.1016/j.ctim.2020.102479. Epub 2020 Jun 11.
The consumption of nuts and edible seeds is associated with the improvement of the metabolic profile and reduction of cardiovascular diseases. However, the effects of its subproducts, such as oil, are still poorly studied. This study aimed to evaluate the effect of the baru almond oil supplementation on inflammation, oxidative stress, body composition, lipid profile, and plasma fatty acids of hemodialysis patients.
In a randomized, double-blind, 12-week placebo-controlled clinical study, hemodialysis patients were supplemented with 5 g of baru oil (BG, n = 17) or 5 g of mineral oil (placebo, BP, n = 12). Body composition, renal function, ultra-sensitive C-reactive protein (us-CRP), oxidative stress, plasma fatty acids, and lipid profile were analysed before and after the intervention.
Patients were aged 50.5 ± 2.2 years and the average time of dialyses was 52,1 ± 42,6 months. The BG decreased us-CRP concentration compared to PG (-1.2 ± 0.2 vs. + 0.8 ± 0.2 mg / L,d = 0.88; p = 0.01). Baru almond oil supplementation was not effective in improving body composition, lipid profile, and oxidative stress.
Baru almond oil supplementation decreased us-CRP concentration in patients with chronic kidney disease under hemodialysis treatment.
食用坚果和可食用种子与改善代谢状况和降低心血管疾病风险有关。然而，其副产品，如油，的影响仍研究不足。本研究旨在评估巴鲁杏仁油补充对血液透析患者炎症、氧化应激、身体成分、血脂谱和血浆脂肪酸的影响。
在一项随机、双盲、12 周安慰剂对照的临床研究中，血液透析患者补充 5g 巴鲁油（BG，n=17）或 5g 矿物油（安慰剂，BP，n=12）。干预前后分析身体成分、肾功能、超敏 C 反应蛋白（us-CRP）、氧化应激、血浆脂肪酸和血脂谱。
患者年龄为 50.5±2.2 岁，透析时间平均为 521±42.6 个月。与 PG 相比，BG 降低了 us-CRP 浓度（-1.2±0.2 与+0.8±0.2mg/L，d=0.88；p=0.01）。巴鲁杏仁油补充对改善身体成分、血脂谱和氧化应激没有效果。
巴鲁杏仁油补充可降低血液透析治疗的慢性肾脏病患者的 us-CRP 浓度。
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