Clinical and Sports Nutrition Research Laboratory (LABINCE), Faculty of Nutrition, Federal University of Goias-UFG, Goiânia, 74605-080 GO, Brazil.
Department of Health Sciences; Faculty of Medicine, University of São Paulo-USP, Ribeirão Preto, 14049-900 SP, Brazil.
Nutrients. 2019 Jul 30;11(8):1750. doi: 10.3390/nu11081750.
Obesity-induced inflammation is frequently associated with higher oxidative stress. In vitro and experimental studies have considered baru almonds (Dipteryx alata Vog) as a legume seed with high antioxidant capacity. The aim of this study was to evaluate whether baru almonds are capable of improving the inflammatory and antioxidant status in overweight and obese women.
In a parallel-arm, randomized placebo-controlled trial, 46 overweight and obese women (age: 40 ± 11 years; body mass index: 33.3 ± 4.3) were randomly assigned to receive advice to follow a normocaloric and isoenergetic diet with placebo (PLA, = 22) or similar advice plus 20 g baru almonds (BARU, = 24) for 8 wk. Malondialdehyde (MDA), adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-10, antioxidant enzymes activities (catalase-CAT; glutathione peroxidase-GPx; superoxide dismutase-SOD), and minerals were analyzed in plasma samples.
At baseline, groups were similar regarding the body composition, oxidative, and inflammatory parameters. The BARU group increased the activity of GPx (+0.08 U/mg, 95%CI + 0.05 to +0.12 vs. -0.07, 95%CI -0.12 to -0.03, < 0.01) and plasma copper concentration ( = 0.037) when compared to the PLA group. No differences were observed between groups in CAT and SOD activity or MDA and cytokines concentrations.
Baru almond supplementation increased the GPx activity in overweight and obese women.
肥胖引起的炎症通常与更高的氧化应激有关。体外和实验研究认为巴尔鲁杏仁（Dipteryx alata Vog）是一种具有高抗氧化能力的豆科种子。本研究旨在评估巴尔鲁杏仁是否能改善超重和肥胖女性的炎症和抗氧化状态。
在一项平行臂、随机、安慰剂对照试验中，46 名超重和肥胖女性（年龄：40 ± 11 岁；体重指数：33.3 ± 4.3）被随机分配接受遵循低热量和等能量饮食的建议加安慰剂（PLA，n = 22）或类似建议加 20 g 巴尔鲁杏仁（BARU，n = 24），共 8 周。分析血浆样本中的丙二醛（MDA）、脂联素、肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10、抗氧化酶活性（过氧化氢酶-CAT；谷胱甘肽过氧化物酶-GPx；超氧化物歧化酶-SOD）和矿物质。
在基线时，两组在身体成分、氧化和炎症参数方面相似。与 PLA 组相比，BARU 组 GPx 活性增加（+0.08 U/mg，95%CI + 0.05 至 +0.12 比 -0.07，95%CI -0.12 至 -0.03， < 0.01），血浆铜浓度增加（ = 0.037）。两组间 CAT 和 SOD 活性或 MDA 和细胞因子浓度无差异。
巴尔鲁杏仁补充剂增加了超重和肥胖女性的 GPx 活性。
