Centre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University of Trás-os-Montes and Alto Douro, UTAD, 5000-801 Vila Real, Portugal.
CECAV-Animal and Veterinary Research Centre, University of Trás-os-Montes and Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal.
Molecules. 2024 May 30;29(11):2576. doi: 10.3390/molecules29112576.
Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.
慢性肾脏病（CKD）是一个严峻的全球性健康问题，影响着每六个 25 岁以上的成年人中的一个。本综述探讨了酚类化合物在管理 CKD 及其并发症方面的潜力。通过研究现有研究，我们强调了它们多样化的生物活性和对抗与 CKD 相关问题的能力。我们分析了这些化合物的营养益处、生物利用度和安全性概况。虽然临床证据很有希望，但临床前研究为潜在机制、最佳剂量和潜在副作用提供了有价值的见解。进一步的研究对于验证酚类化合物治疗 CKD 的疗效至关重要。我们主张继续探索它们在食品、药品和营养保健品中的创新应用。本综述旨在促进科学界努力利用酚类化合物应对与 CKD 相关的挑战。
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