Humphries M J, Matsumoto K, White S L, Olden K
J Natl Med Assoc. 1987 Apr;79(4):411-9.
In this overview the authors describe their recent attempts to specifically interfere with the metastatic spread of B16-F10 melanoma cells. Using the experimental metastasis model system, inhibitory effects of (1) coinjection of cells with synthetic peptides derived from the glycoprotein fibronectin, which possess the ability to disrupt cell adhesion, and (2) treatment of cells with inhibitors of protein glycosylation and oligosaccharide processing have been examined.
在本综述中，作者描述了他们最近为特异性干扰B16-F10黑色素瘤细胞的转移扩散所做的尝试。利用实验性转移模型系统，研究了以下两种方法的抑制作用：（1）将细胞与源自纤连蛋白糖蛋白的合成肽共同注射，这些合成肽具有破坏细胞黏附的能力；（2）用蛋白质糖基化和寡糖加工抑制剂处理细胞。
