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免疫功能正常患者的广泛耐药结核性脊柱骨髓炎：病例报告。

Pre-extensively drug-resistant tuberculosis spondylodiscitis in an immunocompetent patient: a case report.

机构信息

Department of Rheumatology B, El Ayachi Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.

Tuberculosis and Respiratory Disease Diagnostic Center, Bab khmiss, Salé, Morocco.

出版信息

Pan Afr Med J. 2020 Jul 8;36:165. doi: 10.11604/pamj.2020.36.165.21689. eCollection 2020.

DOI:10.11604/pamj.2020.36.165.21689
PMID:32952809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7467892/
Abstract

Pre-extensively drug resistant tuberculosis (pre-XDR-TB) has been an area of growing concern, and posing a threat to global efforts of TB control. We report a case of PreXDR-TB spondylodiscitis with resistance to a Fluoroquinolone, in an immunocompetent patient under antibacillary treatment for pleural tuberculosis, managed with drug sensitivity-based second-line antituberculous drug regimen. Our case shows the challenges of the diagnostic and management of Drug-resistant TB spondylodiscitis.

摘要

广泛耐药结核病前期（pre-XDR-TB）已成为日益关注的领域，对全球结核病控制工作构成威胁。我们报告了一例免疫功能正常的患者在接受抗结核药物治疗胸腔结核时发生氟喹诺酮类药物耐药的 preXDR-TB 脊椎炎，采用基于药敏试验的二线抗结核药物方案进行治疗。我们的病例显示了耐药结核病脊椎炎的诊断和管理的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/537781af7485/PAMJ-36-165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/0fad7bf160fe/PAMJ-36-165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/6ca58c298a09/PAMJ-36-165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/7c481c1c2e1e/PAMJ-36-165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/537781af7485/PAMJ-36-165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/0fad7bf160fe/PAMJ-36-165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/6ca58c298a09/PAMJ-36-165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/7c481c1c2e1e/PAMJ-36-165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2852/7467892/537781af7485/PAMJ-36-165-g004.jpg

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本文引用的文献

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Programmatic management of patients with pre-extensively drug-resistant tuberculosis in Peru, 2011-2014.秘鲁 2011-2014 年耐多药结核病广泛前药物治疗患者的程序化管理。
Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1220-1226. doi: 10.5588/ijtld.17.0900.
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Drug-resistant Spinal Tuberculosis.耐药性脊柱结核
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Multi-drug resistant tuberculous spondylitis: A review of the literature.耐多药结核性脊柱炎：文献综述
Ann Thorac Med. 2016 Oct-Dec;11(4):233-236. doi: 10.4103/1817-1737.191867.
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Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates.gyrB基因突变在泰国临床分离株的广泛耐药和超级耐药结核病中的作用
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A study on pre-XDR & XDR tuberculosis & their prevalent genotypes in clinical isolates of Mycobacterium tuberculosis in north India.印度北部结核分枝杆菌临床分离株中广泛耐药前和广泛耐药结核病及其流行基因型的研究
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Drug treatment of multidrug-resistant osteoarticular tuberculosis: a systematic literature review.多药耐药性骨关节结核的药物治疗：系统文献回顾。
Int J Infect Dis. 2012 Nov;16(11):e774-8. doi: 10.1016/j.ijid.2012.07.011. Epub 2012 Aug 30.
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Drug resistance patterns in 111 cases of drug-resistant tuberculosis spine.111 例耐药性肺结核脊柱耐药模式。
Eur Spine J. 2013 Jun;22 Suppl 4(Suppl 4):647-52. doi: 10.1007/s00586-012-2154-x. Epub 2012 Jan 20.
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Treatment outcomes and survival based on drug resistance patterns in multidrug-resistant tuberculosis.基于耐药模式的耐多药结核病的治疗结果和生存情况。
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Spine (Phila Pa 1976). 2009 Oct 15;34(22):E806-10. doi: 10.1097/BRS.0b013e3181af7797.