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南非广泛耐药结核病的耐药性不断增加。

Increasing drug resistance in extensively drug-resistant tuberculosis, South Africa.

机构信息

Tugela Ferry Care and Research Collaboration, Tugela Ferry, South Africa.

出版信息

Emerg Infect Dis. 2011 Mar;17(3):510-3. doi: 10.3201/eid1703.101363.

DOI:10.3201/eid1703.101363
PMID:21392446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3166021/
Abstract

We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa. Of 19 patients with extensively drug-resistant TB identified during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested. This resistance leaves no effective treatment with available drugs in South Africa.

摘要

我们扩大了南非广泛耐药结核分枝杆菌分离株二线抗结核药物敏感性检测。在 2008 年 2 月至 2009 年 4 月期间发现的 19 例广泛耐药结核患者中，有 13 例（68%）的分离株对所有 8 种测试药物均耐药。这种耐药性使得南非现有的药物治疗无效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/3166021/bb8d3ff62de1/10-1363-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/3166021/38f06c112756/10-1363-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/3166021/bb8d3ff62de1/10-1363-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/3166021/38f06c112756/10-1363-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/3166021/bb8d3ff62de1/10-1363-F2.jpg

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Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa.
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Trop Med Infect Dis. 2023 Jun 9;8(6):315. doi: 10.3390/tropicalmed8060315.
4
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Intermittent treatment interruption and its effect on multidrug resistant tuberculosis treatment outcome in Ethiopia.间歇性治疗中断及其对埃塞俄比亚耐多药结核病治疗结局的影响。
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