Liu Wei-Qin, Wang Dan-Dan, Yang Xiao-Xia, Pan Yan-Yan, Song Xue, Hou Yu-Shan, Wang Chen-Xiao
The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.
Optometry Academy of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.
Int J Ophthalmol. 2020 Sep 18;13(9):1459-1466. doi: 10.18240/ijo.2020.09.19. eCollection 2020.
To explore the topographic distribution features of choroidal thickness (CT) and retinal nerve fiber layer thickness (RNFLT), and determine the relationship between CT and ocular parameters in school-aged children.
The healthy school-aged children with low ametropia or emmetropia in Wenzhou were recruited for this cross-sectional study. With high-density optical coherence tomography (HD-OCT) combined with MATLAB software, the CT and RNFLT values in the macular area were measured at different locations and compared. Statistical analyses were performed to evaluate the correlation between CT and ophthalmic parameters, such as spherical equivalent (SE) and the axial length (AL).
A total of 279 school-aged children with 8.00±1.35 years of mean age (range, 6-10y) were included. The mean AL was 23.66±0.86 mm. The mean CT in CT-C (264.31±48.93 µm) was thicker than that in CT-N1 (249.54±50.52 µm), and the average CT in the parafoveal region was also thicker than that in CT-N2 (235.65±50.63 µm). The subfoveal CT also varied substantially across refractive errors (<0.001), and those with myopia (250.59±47.01 µm) exhibited a thinner choroid compared with those with emmetropia (278.74±48.06 µm). CT negatively correlated with AL (y=-21.72x+779.17; =0.1458), and positively correlated with SE (y=15.76x+271.9; =0.0727, OD; y=18.31x+269.8; =0.1007, OS). The average RNFLT was thickest in the peripapillary region (236.35±19.03 µm), the mean RNFLT-S (131.10±15.16 µm) was thicker than the RNFLT-I (128.20±16.59 µm), and the mean RNFLT-T (76.54±11.99 µm) was thicker than the RNFLT-N (64.28±8.55 µm). The variations in the RNFLT between quadrants did differ between those with myopia and emmetropia (<0.05).
We establish demographic information for the choroid and RNFLT. These findings provide information that should be considered in future analyses of the CT and RNFLT in OCT studies in school-aged children.
探讨学龄儿童脉络膜厚度（CT）和视网膜神经纤维层厚度（RNFLT）的地形图分布特征，并确定CT与眼参数之间的关系。
招募温州地区低屈光不正或正视的健康学龄儿童进行这项横断面研究。使用高密度光学相干断层扫描（HD-OCT）结合MATLAB软件，测量黄斑区不同位置的CT和RNFLT值并进行比较。进行统计分析以评估CT与眼科参数之间的相关性，如等效球镜度（SE）和眼轴长度（AL）。
共纳入279名平均年龄为8.00±1.35岁（范围6 - 10岁）的学龄儿童。平均眼轴长度为23.66±0.86mm。CT-C区域的平均CT（264.31±48.93μm）比CT-N1区域（249.54±50.52μm）厚，黄斑旁区域的平均CT也比CT-N2区域（235.65±50.63μm）厚。黄斑中心凹下CT在不同屈光不正状态下也有显著差异（<0.001），近视儿童（250.59±47.01μm）的脉络膜比正视儿童（278.74±48.06μm）薄。CT与AL呈负相关（y = -21.72x + 779.17； = 0.1458），与SE呈正相关（y = 15.76x + 271.9； = 0.0727，右眼；y = 18.31x + 269.8； = 0.1007，左眼）。平均RNFLT在视乳头周围区域最厚（236.35±19.03μm），平均RNFLT-S（131.10±15.16μm）比RNFLT-I（128.20±16.59μm）厚，平均RNFLT-T（76.54±11.99μm）比RNFLT-N（64.28±8.55μm）厚。近视和正视儿童象限间RNFLT的变化存在差异（<0.05）。
我们建立了脉络膜和RNFLT的人口统计学信息。这些发现为未来学龄儿童OCT研究中CT和RNFLT的分析提供了应考虑的信息。
