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2019年新型冠状病毒疫情期间的分段二次增长

Piecewise quadratic growth during the 2019 novel coronavirus epidemic.

作者信息

Brandenburg Axel

机构信息

Nordita, KTH Royal Institute of Technology and Stockholm University, SE-10691 Stockholm, Sweden.

出版信息

Infect Dis Model. 2020;5:681-690. doi: 10.1016/j.idm.2020.08.014. Epub 2020 Sep 11.

Abstract

The temporal growth in the number of deaths in the COVID-19 epidemic is subexponential. Here we show that a piecewise quadratic law provides an excellent fit during the thirty days after the first three fatalities on January 20 and later since the end of March 2020. There is also a brief intermediate period of exponential growth. During the second quadratic growth phase, the characteristic time of the growth is about eight times shorter than in the beginning, which can be understood as the occurrence of separate hotspots. Quadratic behavior can be motivated by peripheral growth when further spreading occurs only on the outskirts of an infected region. We also study numerical solutions of a simple epidemic model, where the spatial extend of the system is taken into account. To model the delayed onset outside China together with the early one in China within a single model with minimal assumptions, we adopt an initial condition of several hotspots, of which one reaches saturation much earlier than the others. At each site, quadratic growth commences when the local number of infections has reached a certain saturation level. The total number of deaths does then indeed follow a piecewise quadratic behavior.

摘要

新冠疫情中死亡人数的时间增长呈次指数形式。我们在此表明,分段二次定律在1月20日出现前三例死亡后的30天内以及2020年3月底之后能提供极佳的拟合。还存在一个短暂的指数增长中间期。在第二个二次增长阶段,增长的特征时间比开始时短约八倍,这可理解为出现了独立的热点地区。当进一步传播仅发生在受感染区域的边缘时,二次行为可由周边增长来解释。我们还研究了一个简单疫情模型的数值解,其中考虑了系统的空间范围。为了在一个假设最少的单一模型中模拟中国境外的延迟爆发以及中国境内的早期爆发,我们采用了几个热点地区的初始条件,其中一个比其他地区更早达到饱和。在每个地点,当本地感染人数达到一定饱和水平时,二次增长开始。死亡总数确实呈现出分段二次行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/7505809/f2562e3dea69/gr1.jpg

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