Department of Nephrology, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 76 Jiefang Avenue, Wuhan, 430033, Hubei, China.
Department of Respiratory Medicine, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 76 Jiefang Avenue, Wuhan, 430033, Hubei, China.
Int Urol Nephrol. 2021 Jan;53(1):165-169. doi: 10.1007/s11255-020-02646-0. Epub 2020 Sep 20.
This present study aims to investigate the relationship between laboratory parameters on admission and prognosis of coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, as well as providing a theoretical basis for clinical evaluation of prognosis and corresponding intervention measures.
Retrospective analysis was performed on the clinical data of 47 maintenance hemodialysis patients who infected with COVID-19 and admitted to our hospital. According to their clinical outcome, these patients were divided into a survival group (n = 38) and a fatality group (n = 9). Information on the general condition and laboratory parameters of the patients were collected. Laboratory parameters were compared between different groups. The area under the curve (AUC) was used to evaluate the prognosis of COVID-19 in maintenance hemodialysis patients.
Statistically significant differences were observed in age, white blood cell count, neutrophil count, albumin, C-reactive protein (CRP), procalcitonin, and lactate dehydrogenase (LDH) on admission (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the values of AUC of CRP, neutrophil count, LDH, white blood cell count, albumin, and procalcitonin were 0.895, 0.813, 0.758, 0.757, 0.743, and 0.728, respectively.
Laboratory parameters including CRP, neutrophil count, LDH, white blood cell count, albumin, and procalcitonin were predictive on the prognosis of maintenance hemodialysis patients with COVID-19. Among them, CRP was the strongest single predictive laboratory indicator.
本研究旨在探讨维持性血液透析患者 2019 年冠状病毒病（COVID-19）入院时实验室参数与预后的关系，为临床评估预后及相应干预措施提供理论依据。
回顾性分析我院收治的 47 例 COVID-19 感染维持性血液透析患者的临床资料。根据临床转归，将患者分为生存组（n=38）和死亡组（n=9）。收集患者的一般情况和实验室参数资料，比较不同组间实验室参数。采用受试者工作特征（ROC）曲线评估维持性血液透析患者 COVID-19 预后。
入院时年龄、白细胞计数、中性粒细胞计数、白蛋白、C 反应蛋白（CRP）、降钙素原、乳酸脱氢酶（LDH）等实验室参数比较，差异有统计学意义（P<0.05）。ROC 曲线分析显示，CRP、中性粒细胞计数、LDH、白细胞计数、白蛋白、降钙素原的 AUC 值分别为 0.895、0.813、0.758、0.757、0.743、0.728。
CRP、中性粒细胞计数、LDH、白细胞计数、白蛋白、降钙素原等实验室参数对维持性血液透析患者 COVID-19 预后有预测价值，其中 CRP 是最强的单一预测实验室指标。
