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葡萄牙 COVID-19 大流行期间超额死亡的快速估算——超出报告死亡人数。

Rapid Estimation of Excess Mortality during the COVID-19 Pandemic in Portugal -Beyond Reported Deaths.

机构信息

Public Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisboa, Portugal.

Public Health Unit, North Lisbon Health Centers, Lisbon, Portugal.

出版信息

J Epidemiol Glob Health. 2020 Sep;10(3):209-213. doi: 10.2991/jegh.k.200628.001.

Abstract

BACKGROUND

One month after the first COVID-19 infection was recorded, Portugal counted 18,051 cases and 599 deaths from COVID-19. To understand the overall impact on mortality of the pandemic of COVID-19, we estimated the excess mortality registered in Portugal during the first month of the epidemic, from March 16 until April 14 using two different methods.

METHODS

We compared the observed and expected daily deaths (historical average number from daily death registrations in the past 10 years) and used 2 standard deviations confidence limit for all-cause mortality by age and specific mortality cause, considering the last 6 years. An adapted Auto Regressive Integrated Moving Average (ARIMA) model was also tested to validate the estimated number of all-cause deaths during the study period.

RESULTS

Between March 16 and April 14, there was an excess of 1255 all-cause deaths, 14% more than expected. The number of daily deaths often surpassed the 2 standard deviations confidence limit. The excess mortality occurred mostly in people aged 75+. Forty-nine percent (49%) of the estimated excess deaths were registered as due to COVID-19, the other 51% registered as other natural causes.

CONCLUSION

Even though Portugal took early containment measures against COVID-19, and the population complied massively with those measures, there was significant excess mortality during the first month of the pandemic, mostly among people aged 75+. Only half of the excess mortality was registered as directly due do COVID-19.

UNLABELLED

An Excess Mortality (EM) of 1255 deaths were estimated 1 month after the first death classified by COVID-19, and it would probably be more if the government had not taken early action.

UNLABELLED

The age group where a significant increase in mortality was noted was above 75 years.

UNLABELLED

51% of the EM was due to natural causes other than COVID-19.

摘要

背景

在首次记录到 COVID-19 感染一个月后,葡萄牙记录了 18051 例 COVID-19 病例和 599 例 COVID-19 死亡病例。为了了解 COVID-19 大流行对总体死亡率的影响,我们使用两种不同的方法估计了葡萄牙在疫情爆发的第一个月(从 3 月 16 日至 4 月 14 日)登记的超额死亡人数。

方法

我们比较了观察到的和预期的每日死亡人数(过去 10 年中每日死亡登记的历史平均人数),并考虑到过去 6 年,使用了年龄和特定死亡原因的全因死亡率的 2 个标准差置信限。还测试了一个经过修改的自回归综合移动平均(ARIMA)模型,以验证研究期间全因死亡人数的估计值。

结果

在 3 月 16 日至 4 月 14 日期间,全因死亡人数超额 1255 人,比预期多 14%。每日死亡人数经常超过 2 个标准差置信限。超额死亡主要发生在 75 岁以上的人群中。估计的超额死亡中有 49%(49%)被登记为 COVID-19 导致,其他 51%被登记为其他自然原因。

结论

尽管葡萄牙对 COVID-19 采取了早期遏制措施,且民众大规模遵守了这些措施,但在大流行的第一个月仍出现了显著的超额死亡人数,主要集中在 75 岁以上的人群中。只有一半的超额死亡人数被登记为直接由 COVID-19 导致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c102/7509098/a7ed1c892ad4/JEGH-10-3-209-g001.jpg

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