State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188434. doi: 10.1016/j.bbcan.2020.188434. Epub 2020 Sep 18.
Macrophages are important effector cells of the innate immune system and are also major components of the tumor microenvironment (TME). Macrophages that are abundant in the TME are called tumor-associated macrophages (TAMs). As TAMs promote strong tumor angiogenesis and support tumor cell survival, they are closely related to tumor growth. Several studies have demonstrated that reducing the density or effects of TAMs can inhibit the growth of tumors, making them targets for cancer immunotherapy, which has become a research hot spot. Several clinical and preclinical trials have studied drugs that inhibit the effects of and reduce the population of phagocytes that target TAMs achieve cancer immunotherapy. In this paper, we summarize the various methods of targeting TAMs for tumor immunotherapy, focusing on TAM mechanisms, sources, and polarization.
巨噬细胞是先天免疫系统的重要效应细胞，也是肿瘤微环境（TME）的主要组成部分。在 TME 中丰富存在的巨噬细胞称为肿瘤相关巨噬细胞（TAMs）。由于 TAMs 促进了强烈的肿瘤血管生成并支持肿瘤细胞存活，因此它们与肿瘤生长密切相关。几项研究表明，减少 TAMs 的密度或作用可以抑制肿瘤的生长，使其成为癌症免疫治疗的靶点，这已成为研究热点。一些临床前和临床试验已经研究了针对 TAMs 的药物，这些药物可以抑制吞噬细胞的作用并减少其数量，从而实现癌症免疫治疗。在本文中，我们总结了针对 TAMs 的各种肿瘤免疫治疗方法，重点介绍了 TAM 的机制、来源和极化。
