文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

癌症相关成纤维细胞和细胞外囊泡在肿瘤发生中的作用。

The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis.

机构信息

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.

Postgraduate Program in Dentistry, Federal University of Santa Catarina, Florianópolis 88.040-370, Brazil.

出版信息

Int J Mol Sci. 2020 Sep 17;21(18):6837. doi: 10.3390/ijms21186837.

DOI:10.3390/ijms21186837
PMID:32957712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7555043/
Abstract

Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.

摘要

细胞外囊泡 (EVs) 在癌细胞与肿瘤微环境 (TME) 基质成分之间的通讯中发挥关键作用。在这种情况下，癌细胞衍生的 EVs 可以调节 TME 细胞中 CAF 表型的激活，这可以通过几种 EV cargos（例如 miRNA、蛋白质、mRNA 和 lncRNAs）来介导。另一方面，CAF 衍生的 EVs 可以在肿瘤发生过程中介导多种过程，包括肿瘤生长、侵袭、转移和治疗耐药性。本综述旨在讨论 CAFs 和癌细胞之间基于 EV 的串扰的分子方面，此外还评估了 EV cargos 在治疗耐药性和前转移龛形成中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4069/7555043/7d7a5e3c6038/ijms-21-06837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4069/7555043/e26cf49d10a0/ijms-21-06837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4069/7555043/7d7a5e3c6038/ijms-21-06837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4069/7555043/e26cf49d10a0/ijms-21-06837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4069/7555043/7d7a5e3c6038/ijms-21-06837-g002.jpg

相似文献

[1]
The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis.

Int J Mol Sci. 2020-9-17

[2]
Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts.

Mol Cancer. 2019-12-3

[3]
Cancer associated-fibroblast-derived exosomes in cancer progression.

Mol Cancer. 2021-12-1

[4]
Emerging Role of Extracellular Vesicles and Cellular Communication in Metastasis.

Cells. 2021-12-6

[5]
Architecture of Cancer-Associated Fibroblasts in Tumor Microenvironment: Mapping Their Origins, Heterogeneity, and Role in Cancer Therapy Resistance.

OMICS. 2020-6

[6]
Extracellular vesicles released by hypoxia-induced tumor-associated fibroblasts impart chemoresistance to breast cancer cells via long noncoding RNA H19 delivery.

FASEB J. 2024-1-31

[7]
Extracellular vesicle secretion of miR-142-3p from lung adenocarcinoma cells induces tumor promoting changes in the stroma through cell-cell communication.

Mol Carcinog. 2018-11-28

[8]
Role of miRNAs in cell signaling of cancer associated fibroblasts.

Int J Biochem Cell Biol. 2018-5-25

[9]
Proteomes of Extracellular Vesicles From Pancreatic Cancer Cells and Cancer-Associated Fibroblasts.

Pancreas. 2022-8-1

[10]
Reshaping the tumor microenvironment: extracellular vesicles as messengers of cancer cells.

Carcinogenesis. 2020-11-13

引用本文的文献

[1]
Integrative analysis of saliva-derived exosomal proteome and lipidome for the diagnosis of esophageal squamous cell carcinoma.

BMC Cancer. 2025-8-1

[2]
Plasticity and Functional Heterogeneity of Cancer-Associated Fibroblasts.

Cancer Res. 2025-7-29

[3]
Hidden forces: the impact of cancer-associated fibroblasts on non-small cell lung cancer development and therapy.

J Transl Med. 2025-7-25

[4]
Extracellular Vesicles as Biomarkers in Chronic Hepatobiliary Diseases: An Overview of Their Interplay.

Int J Mol Sci. 2025-6-30

[5]
Fibroblast proximity to a tumor impacts fibroblast extracellular vesicles produced by 3D bioprinted stromal models.

Biomater Sci. 2025-6-10

[6]
Metastatic pheochromocytoma complicated with Langerhans cell histiocytosis: a case report.

Front Endocrinol (Lausanne). 2025-4-11

[7]
Extracellular Vesicles Secreted by Cancer-Associated Fibroblasts Drive Non-Invasive Cancer Cell Progression to Metastasis via TGF-β Signalling Hyperactivation.

J Extracell Vesicles. 2025-3

[8]
Single cell analysis reveals that SPP1 macrophages enhance tumor progression by triggering fibroblast extracellular vesicles.

Transl Oncol. 2025-5

[9]
Extracellular Vesicles as Mediators and Potential Targets in Combating Cancer Drug Resistance.

Molecules. 2025-1-23

[10]
A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens.

Nat Commun. 2025-2-6

本文引用的文献

[1]
miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway.

Clin Sci (Lond). 2020-4-17

[2]
Extracellular vesicle packaged LMP1-activated fibroblasts promote tumor progression via autophagy and stroma-tumor metabolism coupling.

Cancer Lett. 2020-3-8

[3]
Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer.

Pathol Res Pract. 2020-5

[4]
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation.

Nat Commun. 2020-3-5

[5]
Cancer associated fibroblasts: phenotypic and functional heterogeneity.

Front Biosci (Landmark Ed). 2020-3-1

[6]
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.

Mol Cancer. 2020-2-27

[7]
Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche.

Oncogenesis. 2020-2-13

[8]
Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma.

Cancer Med. 2020-4

[9]
Inhibiting extracellular vesicles formation and release: a review of EV inhibitors.

J Extracell Vesicles. 2019-12-19

[10]
A framework for advancing our understanding of cancer-associated fibroblasts.

Nat Rev Cancer. 2020-1-24

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索