el Tahir K E, Ageel A M, Abu-Jayyab A R
Prostaglandins. 1987 Jan;33(1):17-24. doi: 10.1016/0090-6980(87)90301-7.
The influence of taurine (in drinking water for 6 weeks) on PGI2 and TXA2 synthesis by some female rat organs was investigated using radioimmunoassay and platelet antiaggregatory bioassay. Taurine 100 and 200 mg/kg/day increased aortic PGI2 release from 0.59 +/- 0.04 (control) to 0.85 +/- 0.05 and 1.01 +/- 0.06 ng/mg, respectively and that by the myometrium from 0.24 +/- 0.02 (control) to 0.38 +/- 0.01 and 0.50 +/- 0.04 ng/mg wet tissue, respectively (P less than 0.05, n = 6). It did not affect PGI2 and TXA2 production in the heart or TXA2 in the aorta. Taurine 200 mg/kg depressed uterine TXA2 synthesis from 148.6 +/- 9.8 (control) to 85.4 +/- 6.8 pg/mg (P less than 0.05, n = 6). Furthermore taurine 0.4 and 0.8 mM in vitro stimulated PGI2 release by the myometrial and aortic tissues from pregnant rats. The stimulant effect of taurine on PGI2 may be related to its antioxidant effect whereas its inhibitory effect on uterine TXA2 may result from direction of synthesis towards PGI2. It is concluded that endogenous taurine may participate in regulation of PGs synthesis and that prostanoids may contribute to its known actions. On broad basis, taurine-induced release of PGI2 may prove of potential value in those ailments characterised by deficiency in PGI2 release.
采用放射免疫分析法和血小板抗聚集生物测定法，研究了牛磺酸（在饮用水中添加6周）对一些雌性大鼠器官合成前列环素（PGI2）和血栓素A2（TXA2）的影响。牛磺酸剂量为100和200mg/kg/天，可使主动脉PGI2释放量分别从0.59±0.04（对照）增加到0.85±0.05和1.01±0.06ng/mg，使子宫肌层PGI2释放量分别从0.24±0.02（对照）增加到0.38±0.01和0.50±0.04ng/mg湿组织（P<0.05，n=6）。它不影响心脏中PGI2和TXA2的产生，也不影响主动脉中TXA2的产生。牛磺酸剂量为200mg/kg时，可使子宫TXA2合成量从148.6±9.8（对照）降低到85.4±6.8pg/mg（P<0.05，n=6）。此外，体外实验中，0.4和0.8mM的牛磺酸可刺激妊娠大鼠子宫肌层和主动脉组织释放PGI2。牛磺酸对PGI2的刺激作用可能与其抗氧化作用有关，而其对子宫TXA2的抑制作用可能是由于合成方向转向了PGI2。研究得出结论，内源性牛磺酸可能参与前列腺素合成的调节，前列腺素可能有助于其已知的作用。从广义上讲，牛磺酸诱导的PGI2释放可能在那些以PGI2释放不足为特征的疾病中具有潜在价值。
