心脏中的牛磺酸和类二十烷酸。
Taurine and icosanoids in the heart.
作者信息
Chanh P H, Chahine R, Pham H C, Dossou-Gbete V, Navarro-Delmasure C
机构信息
C.N.R.S. Institut de Physiologie, Toulouse, France.
出版信息
Prostaglandins Leukot Med. 1987 Aug;28(3):243-54. doi: 10.1016/0262-1746(87)90114-4.
Experiments were carried out on non-working isolated rabbit hearts perfused by Tyrode solution: the effects of Taurine introduced into the coronary circulation were studied on the biosynthesis of the anti-thromboxane synthetase factor ("FATS") and on the TXA2 and PGI2 synthetase activities of cardiac tissue. The effects of Taurine were simultaneously studied on the biosynthesis of TXA2 and PGI2 in vitro. Experiments performed under the adopted conditions have shown that in vitro Taurine did not significantly modify the biosynthesis of TXA2 and PGI2; ex vivo Taurine did not change the biosynthesis of "FATS" but inhibited both TXA2 and PGI2 synthetase activities of the cardiac tissue: Taurine was more active on the TXA2 synthetase activity than on the PGI2 one. Thus Taurine promoted the formation of vasodilator and antiaggregating PGI2 at the expenses of vasoconstrictor and proaggregating TXA2. This could at least partly explain the beneficial effects of Taurine in the physiopathology of the heart.
在由台氏液灌注的非工作状态的离体兔心脏上进行了实验
研究了将牛磺酸引入冠脉循环后对抗血栓素合成酶因子（“FATS”）的生物合成以及对心脏组织中血栓素A2（TXA2）和前列环素（PGI2）合成酶活性的影响。同时研究了牛磺酸对体外TXA2和PGI2生物合成的影响。在所采用的条件下进行的实验表明，体外牛磺酸不会显著改变TXA2和PGI2的生物合成；离体状态下牛磺酸不会改变“FATS”的生物合成，但会抑制心脏组织的TXA2和PGI2合成酶活性：牛磺酸对TXA2合成酶活性的作用比对PGI2合成酶活性的作用更强。因此，牛磺酸以血管收缩和促聚集的TXA2为代价促进了血管舒张和抗聚集的PGI2的形成。这至少可以部分解释牛磺酸在心脏生理病理学中的有益作用。
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