从一名患有严重子宫内膜异位症并伴有严重胃肠道并发症的墨西哥患者血液中分离出耳念珠菌的首例病例。

First case of Candida auris isolated from the bloodstream of a Mexican patient with serious gastrointestinal complications from severe endometriosis.

作者信息

Ayala-Gaytán J Jacobo, Montoya Alexandra M, Martínez-Resendez Michel F, Guajardo-Lara Claudia E, de J Treviño-Rangel Rogelio, Salazar-Cavazos Lorena, Llaca-Díaz Jorge M, González Gloria M

机构信息

Infectious Disease Service, Hospital San Jose, TecSalud, Av. Morones Prieto #3000 Pte, Col. Los Doctores, 64710, Monterrey, Nuevo Leon, Mexico.

Microbiology Department, Universidad Autonoma de Nuevo Leon Facultad de Medicina y Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Av. Madero y Calle Dr. Eduardo Aguirre Pequeño s/n, Colonia Mitras Centro, 64460, Monterrey, Nuevo Leon, Mexico.

出版信息

Infection. 2021 Jun;49(3):523-525. doi: 10.1007/s15010-020-01525-1. Epub 2020 Sep 22.

DOI:10.1007/s15010-020-01525-1

PMID:32960418

Abstract

A 58-year-old woman was diagnosed with severe endometriosis and had multiple gastrointestinal tract complications for many years. Candida auris and C. parapsilosis were isolated from the bloodstream. Identification of C. auris was confirmed by amplification and sequencing of the internal transcriber spacer and the D1/D2 domain of the large rRNA gene subunit. Antifungal susceptibility was tested in both isolates using the Clinical Laboratory Standards Institute protocol M27-A3/S4. The patient evolved favorably with systemic antifungal therapy consisting of caspofungin and liposomal amphotericin B.

摘要

一名58岁女性被诊断为重度子宫内膜异位症，多年来出现多种胃肠道并发症。从血液中分离出耳念珠菌和近平滑念珠菌。通过对大rRNA基因亚基的内部转录间隔区和D1/D2结构域进行扩增和测序，确认了耳念珠菌的鉴定。使用临床实验室标准协会M27 - A3/S4方案对两种分离株进行了抗真菌药敏试验。患者接受了由卡泊芬净和脂质体两性霉素B组成的全身抗真菌治疗，病情好转。