Zhao Naizhuo, Smargiassi Audrey, Colmegna Ines, Hudson Marie, Fritzler Marvin, Bernatsky Sasha
McGill University Health Centre, Montreal, Quebec, Canada.
Université de Montréal and Institut National de Santé Publique du Québec, Montréal, Quebec, Canada.
Arthritis Care Res (Hoboken). 2022 Feb;74(2):236-242. doi: 10.1002/acr.24448. Epub 2021 Dec 27.
To examine associations between sunlight exposure and anti-citrullinated protein antibodies (ACPAs) using general population data in Quebec, Canada.
A random sample of 7,600 individuals (including 786 subjects who were ACPA positive and 201 self-reported rheumatoid arthritis [RA] cases) from the CARTaGENE cohort was studied cross-sectionally. All subjects were nested in 4 census metropolitan areas, and mixed-effects logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) for ACPA positivity related to sunlight exposure, adjusting for sun-block use, industrial fine particulate matter (PM ) exposures, smoking, age, sex, French Canadian ancestry, and family income. We also performed sensitivity analyses excluding subjects with RA, defining ACPA positivity by higher titers, and stratifying by age and sex.
The adjusted ORs and 95% CIs did not suggest conclusive associations between ACPA and sunlight exposure or sun-block use, but robust positive relationships were observed between industrial PM emissions and ACPA (OR 1.19 per μg/m [95% CI 1.03-1.36] in primary analyses).
We did not see clear links between ACPA and sunlight exposure or sun-block use, but we did note positive associations with industrial PM . Future studies of sunlight and RA (or ACPA) should take air pollution exposures into account.
利用加拿大魁北克省的普通人群数据，研究阳光暴露与抗瓜氨酸化蛋白抗体（ACPA）之间的关联。
对CARTaGENE队列中的7600名个体（包括786名ACPA阳性受试者和201名自我报告的类风湿性关节炎[RA]病例）进行横断面研究。所有受试者均来自4个人口普查大都市区，采用混合效应逻辑回归模型计算与阳光暴露相关的ACPA阳性的比值比（OR）和95%置信区间（95%CI），并对防晒霜使用、工业细颗粒物（PM）暴露、吸烟、年龄、性别、法裔加拿大血统和家庭收入进行校正。我们还进行了敏感性分析，排除了患有RA的受试者，通过更高滴度定义ACPA阳性，并按年龄和性别进行分层。
校正后的OR和95%CI未表明ACPA与阳光暴露或防晒霜使用之间存在确凿关联，但在主要分析中观察到工业PM排放与ACPA之间存在显著正相关（每μg/m的OR为1.19[95%CI为1.03-1.36]）。
我们未发现ACPA与阳光暴露或防晒霜使用之间存在明确联系，但确实注意到与工业PM存在正相关。未来关于阳光与RA（或ACPA）的研究应考虑空气污染暴露因素。
