Division of Cardiothoracic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Ann Thorac Surg. 2021 May;111(5):1554-1559. doi: 10.1016/j.athoracsur.2020.07.018. Epub 2020 Sep 19.
Patients with hypertension may develop a thoracic aortic aneurysm (TAA) that can be asymptomatic but potentially life-threatening. We sought to assess the prevalence of asymptomatic TAA among hypertensive patients with a point-of-care screening program using pocket-size mobile echocardiographic (PME) devices.
We prospectively performed transthoracic aortic ultrasound using a PME device on patients attending our hypertension clinics between June 2016 and July 2018. The echo examinations were performed by a research fellow to obtain aortic diameter measurements including the aortic sinus, sinotubular junction, ascending aorta, aortic arch, and descending thoracic aorta through various standard echo views. Images were stored on the PME and transferred to a desktop computer for measurements and further statistical analysis.
During the study period 1529 hypertensive patients (mean age, 62 years [range, 30-85]; 824 men) were recruited. The prevalence of TAA (defined as maximum aortic diameter ≥ 4.5 cm and/or >50% larger than the diameter of the adjacent normal aorta) in our study population was 7.5% (115/1529). Multiple logistic regression analysis identified male gender (odds ratio, 2.120; P < .001) and older age (odds ratio, 1.031; P < .001) as independent factors associated with TAA.
Silent TAA is common among hypertensive patients in Hong Kong. We found the PME device to be effective in detecting TAA in a clinic setting. Such an approach may be useful for early detection of TAA among at-risk patients, allowing aggressive blood pressure control and early surgical intervention to prevent catastrophic complications.
高血压患者可能会发展出无症状但有潜在生命威胁的胸主动脉瘤(TAA)。我们试图评估使用便携式掌上超声心动图(PME)设备进行即时护理筛查计划时高血压患者中无症状 TAA 的患病率。
我们于 2016 年 6 月至 2018 年 7 月期间前瞻性地对就诊于我们高血压诊所的患者使用 PME 设备进行经胸主动脉超声检查。由一名研究员进行超声心动图检查,以获取主动脉窦、窦管交界、升主动脉、主动脉弓和降主动脉的主动脉直径测量值,通过各种标准的超声视图。图像存储在 PME 上,并转移到台式计算机上进行测量和进一步的统计分析。
在研究期间,共招募了 1529 名高血压患者(平均年龄 62 岁[范围 30-85];824 名男性)。我们研究人群中 TAA(定义为最大主动脉直径≥4.5cm 和/或比相邻正常主动脉直径大 50%以上)的患病率为 7.5%(115/1529)。多因素逻辑回归分析确定男性性别(比值比,2.120;P<0.001)和年龄较大(比值比,1.031;P<0.001)是与 TAA 相关的独立因素。
在香港的高血压患者中,无声 TAA 很常见。我们发现 PME 设备在诊所环境中有效检测 TAA。这种方法可能有助于在高危患者中早期发现 TAA,从而进行积极的血压控制和早期手术干预以预防灾难性并发症。