Ala-Kaila K
Scand J Gastroenterol. 1987 Apr;22(3):372-6. doi: 10.3109/00365528709078607.
Twenty-nine patients with chronic renal failure were examined both during the predialytic stage and after active treatment (dialysis, transplantation) for upper GI diseases. They underwent a gastric dose-response secretion test, gastroduodenoscopy, radiologic upper GI series, and fasting serum gastrin determination. Upper GI diseases increased in the active treatment stage. At the time of examination, patients with these diseases had a positive ulcer history, duodenitis, duodenogastric reflux, and blood group O more often in the predialytic stage. Their stimulation sensitivity to pentagastrin and their acid secretion capacity were greater, and they were less achlorhydric. Their fasting serum gastrin level was also lower. They had less endoscopically discovered gastritis, but microscopically, with regard to gastritis, they did not differ from those who did not develop upper GI complications. In conclusion, in chronic renal failure upper GI findings increase after the active treatment. Secretion tests and endoscopy performed before active treatment give an indication of those who will develop upper GI complications during active treatment.
对29例慢性肾衰竭患者在透析前阶段以及针对上消化道疾病进行积极治疗（透析、移植）后均进行了检查。他们接受了胃剂量反应分泌试验、胃十二指肠镜检查、上消化道放射学造影以及空腹血清胃泌素测定。上消化道疾病在积极治疗阶段有所增加。在检查时，患有这些疾病的患者在透析前阶段更常出现溃疡病史、十二指肠炎症、十二指肠胃反流以及O型血。他们对五肽胃泌素的刺激敏感性以及胃酸分泌能力更强，胃酸缺乏的情况较少。他们的空腹血清胃泌素水平也较低。内镜检查发现的胃炎较少，但在显微镜下，就胃炎而言，他们与未发生上消化道并发症的患者并无差异。总之，在慢性肾衰竭中，积极治疗后上消化道病变会增加。在积极治疗前进行的分泌试验和内镜检查可提示哪些患者在积极治疗期间会发生上消化道并发症。
