Association between and end-stage renal disease: A meta-analysis.

AIM

To investigate the prevalence and association of () with end-stage renal disease (ESRD).

METHODS

SA comprehensive literature search was completed from inception until October 2016. Studies that reported prevalence, relative risks, odd ratios, hazard ratios or standardized incidence ratio of among ESRD patients were included. Participants without were used as comparators to assess the association between infection and ESRD. Pooled risk ratios and 95%CI was calculated using a random-effect model. Adjusted point estimates from each study were combined by the generic inverse variance method of DerSimonian and Laird.

RESULTS

Of 4546 relevant studies, thirty-seven observational studies met all inclusion criteria. Thirty-five cross-sectional studies were included in the analyses to assess the prevalence and association of with ESRD. The estimated prevalence of among ESRD patients was 44% (95%CI: 40%-49%). The pooled RR of in patients with ESRD was 0.77 (95%CI: 0.59-1.00) when compared with the patients without ESRD. Subgroup analysis showed significantly reduced risk of in adult ESRD patients with pooled RR of 0.71 (95%CI: 0.55-0.94). The data on the risk of ESRD in patients with were limited. Two cohort studies were included to assess the risk of ESRD in patients with . The pooled risk RR of ESRD in patients with was 0.61 (95%CI: 0.03-12.20).

CONCLUSION

The estimated prevalence of in ESRD patients is 44%. Our meta-analysis demonstrates a decreased risk of in adult ESRD patients.