Drosos A A, Skopouli F N, Galanopoulou V K, Kitridou R C, Moutsopoulos H M
Scand J Rheumatol Suppl. 1986;61:246-9.
We present our experience with small doses of cyclosporine A (CyA), 5 mg/kg/day, in patients with primary Sjögren's syndrome treated for up to 12 months. Subjective improvement in xerostomia occurred at 6 months of treatment, without objective improvement in any sicca parameters. At 12 months, xerostomia improved slightly, but minor salivary gland histology worsened. We conclude that small doses of CyA in patients with primary Sjögren's syndrome for up to 12 months are rather ineffective.
我们介绍了对原发性干燥综合征患者使用小剂量环孢素A（CyA），即5毫克/千克/天，治疗长达12个月的经验。治疗6个月时口干主观症状有所改善，但任何干燥参数均无客观改善。治疗12个月时，口干稍有改善，但小唾液腺组织学情况恶化。我们得出结论，原发性干燥综合征患者使用小剂量CyA治疗长达12个月效果相当不佳。
