Takaya M, Ichikawa Y, Yamada C, Hoshina Y, Horiki T, Uchiyama M
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.
Ryumachi. 1997 Jun;37(3):453-7.
We studied the efficacy of oral pilocarpine hydrochloride (9 mg/day, three times daily) on sicca symptoms in 21 patients with Sjögren's syndrome (SS) of the patients, 19 continued the treatment for at least one month, and subjective improvement of dry mouth and dry eye was observed in 10 patients (53%) and 5 patients (26%), respectively. As adverse effects, diaphoresis was most frequently recognized, but it was generally mild and tolerable. In the four patients who have been taking pilocarpine for 12 months, any severe side effects have not been observed. Since the incidences of clinical improvement of sicca symptoms and adverse effects were comparable with the other studies reported from US or Europe, our treatment protocol using pilocarpine hydrochloride (9 mg/day) was considered as appropriate for Japanese SS patients.
我们研究了口服盐酸毛果芸香碱（9毫克/天，每日三次）对21例干燥综合征（SS）患者干燥症状的疗效。这些患者中，19例持续治疗至少1个月，分别有10例（53%）和5例（26%）的口干和干眼症状有主观改善。作为不良反应，出汗是最常出现的，但一般较轻且可耐受。在服用毛果芸香碱12个月的4例患者中，未观察到任何严重副作用。由于干燥症状临床改善和不良反应的发生率与美国或欧洲报道的其他研究相当，我们使用盐酸毛果芸香碱（9毫克/天）的治疗方案被认为适用于日本SS患者。
