Kmeck Adam, Tancer Robert J, Ventura Cristina R, Wiedman Gregory R
Department of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ 07079, USA.
Antibiotics (Basel). 2020 Sep 19;9(9):620. doi: 10.3390/antibiotics9090620.
Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synergy. This discussion takes place considering resistance, and/or synergy in the extracellular space, at the membrane, and during interaction, and/or removal. Overall, this review shows that researchers require improved definitions of resistance and a more thorough understanding of MAP-resistance mechanisms. The solution to combating resistance may ultimately come from an understanding of how to harness the power of synergistic drug combinations.
膜活性肽（MAPs）长期以来一直被认为是战胜抗微生物耐药微生物的关键。然而，此类肽可能单独并不足够。在本综述中，我们旨在强调一些常见的耐药途径以及一些潜在协同作用的途径。本次讨论是在考虑细胞外空间、细胞膜以及相互作用和/或清除过程中的耐药性和/或协同作用的情况下进行的。总体而言，本综述表明研究人员需要改进对耐药性的定义，并更全面地了解MAP耐药机制。对抗耐药性的解决方案最终可能来自于对如何利用协同药物组合的力量的理解。
